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| 皮肤晚期糖基化终末产物与2型糖尿病周围神经病变的相关性研究 |
| Correlation between skin advanced glycation end products and diabetic peripheral neuropath |
| 投稿时间：2015-05-21 修订日期：2015-08-12 |
| DOI：10.3969/j.issn.1000-0399.2015.12.004 |
| 中文关键词: 周围神经病变 2型糖尿病 晚期糖基化终末产物 |
| 英文关键词: Peripheral neuropath disease Type 2 diabetes Advanced glycation end products |
| 基金项目:中国科学院知识创新工程人才专项基金资助项目(项目编号:083RCl1184);十二五国家科技计划(项目编号:11070403050) |
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| 中文摘要: |
| 目的 分析2型糖尿病(T2DM)伴周围神经病变(DPN)患者皮肤晚期糖基化终末产物(AGEs)水平变化及其临床意义.方法 选择99例T2DM患者,依据神经缺陷评分(NDS)将其分为DPN组和非DPN组,同时选取正常对照组(NC组)35例,测定各组皮肤AGEs和糖化血红蛋白(HbA1c)水平并进行比较.结果 与NC组相比,T2DM患者皮肤AGEs水平明显升高(P<0.05);与非DPN组相比,DPN组患者皮肤AGEs水平明显增(P<0.05),两组HbA1c水平差异无统计学意义(P>0.05).结论 T2DM患者皮肤AGEs水平升高可能参与糖尿病周围神经病变的发生. |
| 英文摘要: |
| Objective To analyze the level changes and clinical significance of skin advanced glycation end products(SAGEs)in patients of type 2 diabetes with peripheral neuropath. Methods According to Neurophy Disability Score, 99 patients with type 2 diabetes were divided into two groups, DPN group and non-DPN group; and 35 cases of non-diabetic patients were selected as normal controls. Results Compared with normal control group, SAGEs level was obviously increased in patients with diabetes(P<0.05), compared with non-DPN group, the level of SAGEs also increased in DPN group. There was no significant difference in the HbA1c level between DPN group and non-DPN group(P>0.05). Conclusion The SAGEs level is obviously increased in patients with type 2 diabetes, which may be involved in the pathogenesis of DPN. |
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