| Objective To analyze the serum interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α) levels and its significance before and after infant cytomegaloviru(CMV) hepatitis treatment. Methods A total of 120 cases of CMV hepatitis baby in our department were selected. The children in CMV group were divided into group with and without therapy. Serum, urine and B-ultrasound index were tested. The correlation was analyzed in CMV group before treatment in terms of serum IL-18, TNF-α and liver function. Results The serum IL-18, TNF-α, ALT, AKP, TBIL, γ-GT, the length of the right clavicle midline liver ribs, left clavicle midline ribs and spleen length CMV-DNA quantitative urine in group with therapy were significantly higher than those in the group without therapy(P<0.05). There was positive correlation between TNF-α and ALT, AKP, and between IL-18 and ALT, AKP (P<0.05). Conclusion In the diagnosis of infants with CMV hepatitis, the serum IL-18, TNF-α levels can be used in the evaluation of the extent of damage of liver function, and also in the prediction of the efficacy of anti-viral therapy. |
