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| 可溶性ST2作为慢性心力衰竭预后评估标志物的Meta分析 |
| Prognostic role of soluble ST2 in chronic heart failure:a Meta-analysis |
| 投稿时间：2015-08-05 |
| DOI：10.3969/j.issn.1000-0399.2016.03.009 |
| 中文关键词: ST2,可溶性 心力衰竭 预后 全因性死亡 |
| 英文关键词: ST2,solubility Heart failure Prognosis All-cause mortality |
| 基金项目:池州市市级科研基金项目(项目编号:2013A03) |
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| 中文摘要: |
| 目的 评估可溶性ST2在慢性心力衰竭预后中的预测价值。方法 对PubMed、EMBASE、SODS、中国知网、中国生物医学文献、万方等数据库及Cochrane图书馆进行检索,筛选出与可溶性ST2评估慢性心力衰竭预后相关的中英文文献,提取基本资料、风险比(HR)及95%置信正间(95% CI),采用Stata 11.0进行Meta分析。结果 共纳入7篇符合文献,异质性检验结提示研究间存在异质性。采取随机效应模型合并效应量,单因素分析合并效应HR=1.62,95% CI:1.48~1.77;多因素分析合并效应HR=1.14,95% CI:1.08~1.21。敏感性分析结果提示本次Meta分析结果稳定性较好。结论 可溶性ST2是慢性心力衰竭不良预后的独立预测因子。 |
| 英文摘要: |
| Objective To evaluate the predictive value of soluble ST2 in the prognosis of chronic heart failure.Methods PubMed, EMBASE, SODS, CNKI, CBM and Wanfang database and the Cochrane library were searched. English and Chinese articles were found evaluating the prognosis of chronic heart failure. Baseline data and hazard ratio(HR) and 95% confidence interval(CI) were extracted and analyzed using Stata 11.0 software. Results Seven qualified literatures were included. Heterogeneity test indicated that heterogeneity existed between these studies. Statistics was combined using a random effects model. Combined effect of single variable analysis result, combined HR was 1.62 and 95% CI was 1.48~1.77. Conclusion Effect of multivariable analysis result, HR was 1.14 and 95% CI was 1.08~1.21. The sensitivity analysis indicated that the results of Meta-analysis was stable. Conclusion Soluble ST2 is an independent risk factor for poor prognosis of CHF patients. |
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