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| 化疗联合放疗与单纯放疗治疗胶质瘤的疗效分析 |
| Analysis of effect of chemotherapy combined with radiotherapy and radiotherapy alone on glioma |
| 投稿时间：2015-09-29 |
| DOI：10.3969/j.issn.1000-0399.2016.03.012 |
| 中文关键词: 替莫唑胺 尼莫司汀 放疗 胶质瘤 |
| 英文关键词: Temozolomide Nimustine Radiotherapy Glioma |
| 基金项目: |
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| 摘要点击次数: 1655 |
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| 中文摘要: |
| 目的 比较替莫唑胺联合放疗、尼莫司汀联合放疗及单纯放疗三种治疗方法对胶质瘤的疗效。方法 收集安徽医科大学第一附属医院2008年1月至2013年9月收治的197例脑胶质瘤患者,术后均经病理证实。接受替莫唑胺联合放疗(I组)的患者66例,接受尼莫司汀联合放疗(Ⅱ组)的患者64例,接受单纯放疗(Ⅲ组)的患者67例。统计并比较3组患者近期疗效、1年、2年、3年生存率、总体生存时间及不良反应发生率。结果 3组患者的近期有效率分别为66.7%,35.9%和19.4%,差异有统计学意义(P<0.05)。3组患者的1年生存率差异有统计学意义(P<0.05);而2年生存率和3年生存率的差异无统计学意义(P>0.05)。与Ⅱ组和Ⅲ组相比,I组患者的总体生存时间延长,且不增加不良反应发生率。结论 胶质瘤术后联合放化疗治疗可以提高疗效,替莫唑胺联合放疗治疗胶质瘤的疗效明显优于尼莫司汀联合放疗及单纯放疗。 |
| 英文摘要: |
| Objective To compare the effect of temozolomide combined with radiotherapy, nimustine combined with radiotherapy and radiotherapy alone on glioma.Methods In this 5-year study, 197 patients were confirmed glioma histologically, in which 66 patients received radiotherapy followed by temozolomide(Group I), 64 patients received nimustine combined with radiotherapy(Group Ⅱ) and 67 patients received radiotherapy alone(Group Ⅲ). The short-term efficacy, 1-year, 2-year, 3-year survival rate, overall survival time and adverse reaction rate of the three groups were compared.Results The short-term effective rate of these three methods was 66.7%, 35.9% and 19.4%(P<0.05), respectively. The difference of 1-year survival rate was statistically significant(P<0.05). But there were no statistically significant difference in 2-year and 3-year survival rates(P>0.05). The overall survival time in group I was prolonged without increasing the incidence of adverse reactions when compared to group Ⅱ and Ⅲ.Conclusion The patients of glioma treated with chemotherapeutic drugs combined with radiotherapy obtain a statistically significant better benefit of survival than those treated with radiotherapy alone. Temozolomide therapy is better than the other therapies. |
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