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| α-Klotho在肾性甲状旁腺功能亢进患者甲状旁腺组织中表达的研究 |
| Involvement of α-Klotho in development of renal secondary hyperparathyroidism |
| 投稿时间：2015-12-10 |
| DOI：10.3969/j.issn.1000-0399.2016.04.003 |
| 中文关键词: α-Klotho 继发性甲状旁腺功能亢进 慢性肾脏病 |
| 英文关键词: α-Klotho Secondary hyperparathyroidism Chronic kidney disease |
| 基金项目:北京市科委首都临床特色应用研究资助项目(项目编号:D101100050010025) |
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| 中文摘要: |
| 目的 探讨甲状旁腺α-Klotho蛋白在肾性甲状旁腺功能亢进发生、发展中的作用。方法 入选14例因尿毒症伴甲状旁腺功能亢进而在中日友好医院行甲状旁腺切除术的患者,并收集增生的甲状旁腺50枚;5例甲状腺癌患者因甲状腺手术而连带切除的甲状旁腺5枚作为对照组。用免疫组织化学染色法检测甲状旁腺α-Klotho蛋白的表达水平。结果 与正常甲状旁腺相比,增生的甲状旁腺α-Klotho蛋白表达显著减少(30.3% VS 9.9%),且随着甲状旁腺病理程度的进展而进一步下降(弥漫性增生12.2%,结节性增生10.1%,腺瘤样增生8.2%)。结论 尿毒症患者增生的甲状旁腺α-Klotho蛋白表达明显减少,可能在肾性继发性甲状旁腺功能亢进的发生、发展过程中起重要作用。 |
| 英文摘要: |
| Objective To investigate α-Klotho protein in the role of renal hyperparathyroidism development. Methods Hyperplastic parathyroid glands(n=50)were obtained from 14 patients with renal secondary hyperparathyroidism and surgically resected at China-Japan Friendship Hospital. Normal parathyroid was obtained from glands inadvertently removed in conjunction with thyroidectomy from patients(n=5)with thyroid carcinoma. Immunohistochemical staining was used to detect the level of α-Klotho protein in parathyroid.Results Compared with the normal parathyroid, the level of α-Klotho protein was significantly reduced in hyperplastic parathyroid(30.3% VS 9.9%), and with the progress of parathyroid pathological degree of further reducing(diffuse type 12.2%, nodular type 10.1%, adenomatoid type 8.2%).Conclusion The expression of α-Klotho protein decreases in hyperplastic parathyroid, which may play an important role in the pathogenesis of secondary hyperparathyroidism. |
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