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| MTHFR C677T与缺血(出血)性脑卒中风险相关性评估 |
| Association of MTHFR C677T polymorphism with ischemic and hemorrhagic stroke risks |
| 投稿时间：2015-09-23 |
| DOI：10.3969/j.issn.1000-0399.2016.04.004 |
| 中文关键词: 亚甲基四氢叶酸还原酶 基因多态性 缺血性卒中 出血性卒中 |
| 英文关键词: Methylene tetrahydrofotate reductase(MTHFR) Polymorphism Ischemic stroke Hemorrhagic stroke |
| 基金项目:国家自然科学基金资助项目(81141116) |
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| 中文摘要: |
| 目的 本研究旨在探讨在中国安徽人群中MTHFR C677T基因多态性和脑卒中发生风险的相关性。方法 这项病例对照研究收集了561例样本,其中259例脑梗塞者、96例脑出血者和206例健康对照。利用PCR-RFLP技术来检测MTHFR C677T(Ala222Val)基因多态性位点。结果 多元logistic回归分析结果显示:MTHFR C677T多态性位点与卒中各亚型包括大血管动脉粥样硬化性梗死、心源性梗死、小血管闭塞性梗死、其他确切原因梗死和出血性卒中五种亚型发生风险均没有显著相关性,但是携带MTHFR 677TT基因型的梗塞性卒中患者和DBP显著相关[(5.6±2.3)mmHg,P=0.015],即677TT基因型患者DBP水平要显著高于其他基因型携带者。结论 尽管MTHFR C677T基因多态性不影响缺血性卒中、出血性卒中发生风险,但可能影响卒中患者的血压水平。 |
| 英文摘要: |
| Objective Our aim was to investigate the association between the C677T polymorphism in the MTHFR gene and stroke risk in Anhui population.Methods This case-control study investigated 561 subjects, of them, 259 ischemic stroke(IS), 96 hemorrhagic stroke, and 206 healthy controls. PCR-RFLP was used for the genotyping of MTHFR C677T(Ala222Val).Results Multiple Logistic regression models identified that MTHFR C677T gene polymorphism was not associated with all six subtypes of stroke(including great vessel atherosclerosis infarct, cardiogenic infarct, small vascular occlusive infarct, the exact cause infarct, and hemorrhagic stroke). However, the patients with ischemic stroke harboring MTHFR 677TT genotype had significantly higher DBP levels compared with 677CC(adjusted β±se:5.6±2.3 mmHg, P=0.015).Conclusion MTHFR C677T gene polymorphism is neither associated with hemorrhagic stroke nor with ischemic stroke, but it may influence the blood pressure level in patients with ischemic stroke. |
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