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| 胸苷激酶1在上皮性卵巢癌诊断中的应用 |
| Research of thymidine kinase 1(TK1) in diagnosis of epithelial ovarian cancer |
| 投稿时间：2015-12-10 |
| DOI：10.3969/j.issn.1000-0399.2016.04.006 |
| 中文关键词: 胸苷激酶1 上皮性卵巢癌 卵巢良性肿瘤 诊断 |
| 英文关键词: Thyrnidine kinase 1 Epithelial ovarian cancer Benign ovarian tumor Diagnosis |
| 基金项目:国家自然科学基金项目(项目编号:81300514) |
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| 中文摘要: |
| 目的 探讨胸苷激酶1在上皮性卵巢癌术前诊断中的应用价值。方法 选取2014年1月至2015年10间在安徽医科大学第一附属医院妇产科就诊的上皮性卵巢癌患者100例,另选取门诊女性健康体检者33例作为对照组,依据病理诊断和临床分期进行分组,其中门诊健康者(A组)33例作为对照组,上皮性卵巢癌Ⅰ期(B组)35例,上皮性卵巢癌Ⅱ期(C组)34例,上皮性卵巢癌Ⅲ期(D组)31例,所有病例均测量外周静脉血胸苷激酶1的浓度,统计各组患者胸苷激酶1数值,分析各组数据间差异。结果 胸苷激酶1浓度在A、B、C、D四组分别为(0.963±0.36)pmol/L、(1.68±1.48)pmol/L、(2.96±2.17)pmol/L、(4.60±2.59)pmol/L,A组浓度值较B、C、D低,B组较C、D组低,C组较D组低,差异均具有统计学意义(P<0.05)。结论 上皮性卵巢癌患者的胸苷激酶1浓度较健康者升高,并与患者临床分期呈正比。 |
| 英文摘要: |
| Objective To explore the value of thymidine kinase(TK1)in the diagnosis of epithelial ovarian cancer(EOC). Methods A total of 133 cases were admitted to this hospital from Jan 2014 to Oct 2015, of whom 33 cases were healthy women from medical examination center(Group A), and 35 cases were diagnosed as stage ⅠEOC(Group B), and 34 cases as stage Ⅱ EOC(Group C), another 31 cases as stage Ⅲ EOC(Group D), then the concentration value of TK1 was tested in all patients, and the difference was compared and analysed.Results The concentration value of TK1 of the four groups was(0.963±0.36)pmol/L in Group A, (1.68±1.48)pmol/L in Group B, (2.96±2.17)pmol/L in Group C and(4.60±2.59)pmol/L in Group D, respectively. The level of TK1 in group A was lower than that of the others, the level in group B was lower than that in group C and D, the level in group C was lower than that in group D, and all the difference was statistically significant(P<0.05).Conclusion The EOC patients have a higher level of TK1, which is positively correlated with the clinical stage of patients. |
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