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| 瑞舒伐他汀联合厄贝沙坦对原发性高血压早期肾损伤患者肾脏功能及其他实验室指标的影响 |
| Effects of rosuvastatin combined with irbesartan on renal function and laboratory indexes in patients with primary hypertension and early renal impairment |
| 投稿时间：2015-11-23 |
| DOI：10.3969/j.issn.1000-0399.2016.05.013 |
| 中文关键词: 瑞舒伐他汀 厄贝沙坦 原发性高血压 肾损伤 |
| 英文关键词: Rosuvastatin Irbesartan Primary hypertension Renal impairment |
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| 中文摘要: |
| 目的 探讨瑞舒伐他汀联合厄贝沙坦对原发性高血压早期肾损伤患者肾脏功能及实验室指标的影响。方法 将原发性高血压早期肾损伤患者60例随机分为两组,分别给予厄贝沙坦单用(对照组)和与瑞舒伐他汀联用(试验组);比较两组患者肾功能及实验室指标,评价其临床疗效。结果 对照组患者治疗后总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)水平分别为(5.65±1.36)mmol/L、(2.18±0.85)mmol/L、(3.70±0.97)mmol/L、(1.18±0.63)mmol/L;试验组患者治疗后TC、TG、LDL-C及HDL-C水平分别为(3.94±0.80)mmol/L、(1.62±0.46)mmol/L、(2.26±0.64)mmol/L、(1.45±0.73)mmol/L;对照组患者治疗后血肌酐(Scr)、血尿素氮(BUN)及24 h尿白蛋白定量水平分别为(79.15±17.25)mmol/L、(5.37±1.07)mmol/L、(73.54±16.34)mmol/L;试验组患者治疗后Scr、BUN及24 h尿白蛋白定量水平分别为(75.70±14.84)mmol/L、(4.92±0.98)mmol/L、(57.32±12.94)mmol/L;试验组患者治疗后血脂和肾脏功能指标均显著优于对照组,差异有统计学意义(P<0.05);试验组患者治疗后β2-MG、Cys-C、hs-CRP及ET-1水平均显著低于对照组,差异有统计学意义(P<0.05)。结论 瑞舒伐他汀联合厄贝沙坦治疗原发性高血压早期肾损伤患者效果确切。 |
| 英文摘要: |
| Objective To investigate the effects of rosuvastatin combined with irbesartan on the renal function and laboratory indexes in the patients with primary hypertension and early renal impairment. Methods 60 cases of patients with primary hypertension and early renal impairment were randomly divided into two groups for treatment of irbesartan alone or irbesartan combined with rosuvastatin, and the clinical effects between the two groups were compared on the basis of their renal function and laboratory indexes. Results The serum levels of TC, TG, LDL-C and HDL-C in the control group(irbesartan alone) after treatment were(5.65±1.36) mmol/L, (2.18±0.85) mmol/L, (3.70 mmol/L and(1.18±0.63) mmol/L, respectively;and the levels of TC, TG, LDL-C and HDL-C in the experiment group(irbesartan combined with rosuvastatin) were(3.94±0.80) mmol/L, (1.62±0.46) mmol/L, (2.26±0.64) mmol/L and(1.45±0.73) mmol/L, respectively. The blood levels of Scr, BUN and the concentration of 24 h urinary albumin in the control group after treatment were(79.15±17.25) mmol/L, (5.37±1.07) mmol/L, (73.54±16.34) mmol/L, respectively;and the levels of Scr, BUN and the concentration of 24 h urinary albumin in the experiment group were(75.70±14.84) mmol/L, (4.92±0.98) mmol/L, (57.32±12.94) mmol/L, respectively. The indexes of blood lipids and renal function in the experiment group after treatment were significantly better than those in the control group(P<0.05). The levels of β2-MG, Cys-C, hs-CRP and ET-1 in the experiment group after treatment were significantly lower than those in the control group(P<0.05). Conclusion Application of rosuvastatin combined with irbesartan in treatment of the patients with primary hypertension and early renal impairment has the exact therapeutic effects. |
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