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| 右美托咪定在重症手足口病患者中的应用效果 |
| Application of dexmedetomidine in patients with severe hand, foot and mouth disease |
| 投稿时间：2015-11-28 |
| DOI：10.3969/j.issn.1000-0399.2016.05.019 |
| 中文关键词: 右美托咪啶 手足口病 心率 |
| 英文关键词: Dexmedetomidine Hand, foot and mouth disease Heart rate |
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| 中文摘要: |
| 目的 探讨右美托咪定(DEX)治疗心率增快的重症手足口病(HFMD)患者中的疗效、用法及安全性。方法 将心率增快的重症HFMD患者随机分为DEX组(n=36)、对照组(n=29),比较两组心率控制率、肺水肿/出血发生率;观察DEX应用时间、剂量及不良反应。结果 DEX组1 h及24 h的心率控制率高于对照组,差异有统计学意义(83.33% vs 34.48%,91.67% vs 62.07%,P<0.05),肺水肿/出血发生率组间差异无统计学意义(P>0.05)。DEX有效剂量为(0.86±0.28)μg/(kg·h),中位起效时间为25 min,停药时间为(36.00±14.01)h。2例停DEX后心率反弹。结论 DEX可有效控制重症HFMD的心率,治疗剂量下安全有效。 |
| 英文摘要: |
| Objective To explore the clinical efficacy, application, and safety of dexmedetomidine(DEX) in patients with severe hand, foot and mouth disease(HFMD) accompanied with high heart rate. Methods The patients with severe HFMD accompanied with high heart rate were randomly divided into the DEX group(n=36) and the control group(n=29). The success rate of heart rate control and the incidence of pulmonary edema or hemorrhage were compared between the two groups. The application time, dosage, and adverse reactions of DEX were observed. Results The success rate of heart rate control at 1 h and 24 h after treatment in the DEX group was significantly higher than those in the control group(83.33% vs 34.48%, 91.67% vs 62.07%, P<0.05). The incidence of pulmonary edema or hemorrhage was of no significant difference between the two groups. The effective dose of DEX was 0.86±0.28 μg/(kg·h) and the median onset time was 25 minutes. The DEX withdrawal time was 36.00±14.01 hours, and heart rate of two cases rebounded after DEX withdrawal. Conclusion The high heart rate of severe HFMD can be effectively controlled by DEX application, and it is safe and effective in the therapeutic dosage. |
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