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| 绝经后女性血尿酸水平与冠心病及冠状动脉病变程度的相关性 |
| Relation between serum uric acid levels and presence and severity of coronary artery disease in postmenopausal women |
| 投稿时间：2015-10-07 |
| DOI：10.3969/j.issn.1000-0399.2016.07.002 |
| 中文关键词: 冠心病 血尿酸 女性,绝经后 Gensini评分 |
| 英文关键词: Coronary artery disease Serum uric acid Postmenopausal women Gensini score |
| 基金项目:安徽高校自然科学基金（项目编号：KJ2015ZD24） |
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| 中文摘要: |
| 目的 探讨绝经后女性冠心病及冠脉病变程度与血尿酸（SUA）水平的相关性。方法 回顾性分析2012年8月至2015年8月安徽医科大学第一附属医院602例疑诊为冠心病（CAD）的绝经后女性，根据冠脉造影结果分为CAD组381例和非CAD组221例，观察两组年龄、吸烟、高血压病、糖尿病、高脂血症、SUA水平与冠心病的关系。再以冠脉病变支数和Gensini积分评价绝经后女性CAD组患者冠脉病变的范围和程度，并分析其与SUA水平之间的关系。结果 ①绝经后女性CAD组SUA水平明显高于非CAD组，差异有统计学意义（P < 0.05）。②logistic回归分析显示，绝经后女性冠心病的独立危险因素为年龄、高血压病、低密度脂蛋白胆固醇（LDL-C）、SUA。③冠状动脉三支病变组SUA水平高于双支病变组，差异有统计学意义（P < 0.05），也高于单支病变组，差异有统计学意义（P < 0.05），双支病变组SUA水平高于单支病变组，差异有统计学意义（P < 0.05）。④Spearman相关分析显示SUA水平与Gensini评分呈正相关（rs=0.446，P < 0.05）。结论 SUA水平的升高与绝经后女性冠心病发生密切相关，且与冠脉病变严重程度相关。 |
| 英文摘要: |
| Objective To observe the relationship between serum uric acid(SUA)levels and the presence and severity of coronary artery disease(CAD)in postmenopausal women.Methods The clinical data of 602 postmenopausal women patients with suspected CAD were retrospectively analyzed in the study.Patients were divided into CAD group(n=381)and non-CAD group(n=221)according to the results of coronary angiography.The age,smoking history,hypertension,diabetes mellitus,hyperlipidemia and SUA levels were observed in two groups and their correlation with CAD was studied.Then CAD group were subdivided into single vessel lesion group,double vessel lesion group and triple vessel lesion group.SUA levels were measured,and its relation in the three subgroups was analyzed.The severity of CAD was assessed by the Gensini score.Results ①SUA levels were higher in CAD group than those in non-CAD group(P < 0.05).②Logistic regression analysis showed that the age,hypertension,LDL-C,SUA were the independent risk factors of CAD.③SUA levels were significantly different among the three subgroups(P < 0.05).④The positive correlation was found between SUA levels and Gensini score in CAD group(rs=0.446,P < 0.05).Conclusion SUA level is an independent risk factor,which has a positive correlation with the severity of CAD in postmenopausal women. |
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