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| G试验对肺结核患者肺部真菌感染的早期诊断价值 |
| The early diagnostic value of G test for pulmonary fungal infection in patients with pulmonary tuberculosis |
| 投稿时间：2015-10-21 |
| DOI：10.3969/j.issn.1000-0399.2016.09.015 |
| 中文关键词: 肺结核 真菌感染 (1-3)-β-D-葡聚糖 真菌培养 |
| 英文关键词: Pulmonary tuberculosis Fungal infection (1-3)-β-D-glucan Fungal culture |
| 基金项目: |
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| 摘要点击次数: 2083 |
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| 中文摘要: |
| 目的 对肺结核疑似真菌感染患者血浆（1-3）-β-D-葡聚糖检测（G试验）和真菌培养结果进行比较，评估G试验对肺部真菌感染的早期诊断价值。方法 选取安徽省胸科医院2014年1月至2015年9月明确诊断为肺结核并且高度疑似真菌感染的患者60例，抽取静脉血分离血浆，检测（1-3）-β-D-葡聚糖含量；同时留取痰液行真菌培养加药敏检测，并进行统计学分析。结果 60例疑似肺部真菌感染的患者中，G试验检测阳性率为56.67%，痰真菌培养阳性率为51.67%，差异无统计学意义（χ2=0.07，P=0.30）。结论 G试验具有快速、早期、简便等特点，对肺结核合并侵袭性肺部真菌感染患者的早期诊断具有重要的临床意义。 |
| 英文摘要: |
| Objective To value the early diagnostic value of (1-3)-β-D-glucan in plasma for pulmonary fungal infection in patients with pulmonary tuberculosis. Methods Sixty patients were definitely diagnosed as tuberculosis and highly suspected of having pulmonary fungal infections in our hospital from January 2014 to September 2015. Venous blood was taken and plasma was separated in order to determine the level of (1-3)-β-D-glucan in plasma. Sputum was collected for fungal culture and drug sensitivity test at the same time. Results were analyzed statistically. Results Using traditional culture method,31 positive cases were found in total 60 patients suspected of having pulmonary fungal infections,occupying 51.67%. 34 positive cases were detected using G test,occupying 56.67%. There were no statistically significant differences (χ2=0.07,P=0.30) in the positive rate at which the two methods detected pulmonary fungal infections. Conclusion G test appears to be an rapid,early and simple method.It has important clinical significance in the early diagnosis of invasive pulmonary fungal infection in patients with pulmonary tuberculosis. |
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