Objective Using evidence-based medicine method to analyse the risk factors of bronchopulmonary dysplasia(BPD) among very low birth weight infants. Methods PubMed, Embase, Wan-fang database, China journal full-text database and Chinese science and technology journal full-text database, the Cochrane controlled clinical trials database, Chinese biomedical literature database (CBM) were searched systematically from their establishment to May 2016. The quality of literature was evaluated and software Stata 11.0 was used for a meta-analysis. Results Fifteen controlled trials were included in the study. Meta analysis showed premature rupture of membranes (OR=1.90, 95% CI:1.16-3.11), pulmonary hyaline membrane disease (OR=6.46, 95% CI:4.47-9.35), oxygen time (RR=3.01, 95% CI:1.34-4.69), and pulmonary infection (OR=15.76, 95% CI:7.51-33.07), after birth asphyxia (OR=2.23, 95% CI:1.09-4.57), prenatal infection (OR=3.41, 95% CI:2.40-4.84), PDA (OR=3.39, 95%CI:2.04-5.64), gestational age (RR=2.34, 95% CI:2.34-1.27), birth weight (RR=2.08, 95% CI:2.08-1.21) were risk factors of bronchial pulmonary dysplasia of VLBW infants; prenatal application of PS (OR=4.09, 95% CI:1.65-10.12) was the protective factor. Conclusion Preventive measures should be taken to reduce the risk factors for BPD of VLBW infants to reduce the incidence of it and prolong the survival and improve the long-term quality of life. |