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| 75岁及以上老年食管癌患者调强放疗近期疗效及影响因素 |
| The short-term efficacy and safety of intensity-modulated radiotherapy for elderly patients with esophageal cancer |
| 投稿时间：2016-01-23 |
| DOI：10.3969/j.issn.1000-0399.2016.10.010 |
| 中文关键词: 食管癌 调强放疗 老年患者 |
| 英文关键词: Esophageal cancer Intensity-modulated radiotherapy Elderly patients |
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| 中文摘要: |
| 目的 探讨75岁及以上老年食管癌患者调强放疗的近期效果及安全性。方法 选择2011年11月至2015年11月安徽医学大学第二附属医院不宜或拒绝手术且无远处转移的75岁及以上老年食管癌患者49例，均行调强放疗，总剂量6 000 cGy。观察放疗过程中患者的急性不良反应，放疗结束后1个月，采用钡餐造影结合CT检查评价近期疗效。结果 49例患者中，完全缓解13例，部分缓解27例，无变化5例，病情进展4例，总有效率为81.63%（40/49）。不良反应多为1～2级，经对症处理后症状缓解。未发生3级及以上不良反应。结论 调强放疗治疗75岁及以上老年食管癌患者近期疗效较好，且较为安全，可作为老年食管癌患者改善症状，提高生活质量的主要治疗手段。 |
| 英文摘要: |
| Objective To assess the short-term efficacy and safety of intensity-modulated radiotherapy(IMRT) for elderly patients(≥75years old) with esophageal cancer. Methods Forty-nine cases of patients with esophageal cancer, who were not suitable for surgery or refused surgery and had no distant metastasis, were treated by IMRT. The prescribed dose was 6000cGy. Acute adverse effects were observed during radiotherapy, and the short-term effect was evaluated one month later.Results For 49 cases of patients, CR was in 13 cases, PR in 27 cases and NR in 9 case; the effective rate was 81.63%. The major adverse effects were mainly in grade 1-2, clinical symptoms were remission after treatment, level 3 and above adverse reactions did not occur. Conclusion IMRT therapy treatment for elder patients with esophageal cancer has significant effect and safety, which can remit symptoms and improve the patients' quality of life. |
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