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| 糖化血红蛋白水平与妊娠期糖尿病患者不良妊娠结局的相关性分析 |
| Relationship of glycated hemoglobin levels and adverse pregnancy outcomes in patients with gestational diabetes mellitus |
| 投稿时间：2016-04-22 |
| DOI：10.3969/j.issn.1000-0399.2016.11.007 |
| 中文关键词: 糖化血红蛋白 妊娠期糖尿病 不良妊娠结局 价值 |
| 英文关键词: Glycated hemoglobin Gestational diabetes mellitus Adverse pregnancy outcome Value |
| 基金项目:秦皇岛市科技支撑计划项目（项目编号：201302A158） |
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| 中文摘要: |
| 目的 探讨糖化血红蛋白（HbAlc）水平与妊娠期糖尿病患者不良妊娠结局的相关性。方法 随机选取2014年1月至2015年5月在秦皇岛市工人医院妇产科接受妊娠期糖尿病治疗的120例患者为观察组，同期随机抽取进行产检的非GDM孕妇120例为对照组，严格监控观察组患者的血糖水平，并追踪回访直至患者终止妊娠。记录两组患者HbAlc水平、早产、羊水过多、胎儿过大、胎膜早破等一系列妊娠不良结局以及新生儿低血糖的发生情况。结果 观察组早产、羊水过剩、胎儿过大、胎儿窘迫等妊娠不良结局以及新生儿低血糖的发生率高于对照组，差异均有统计学意义（P均<0.05）；观察组妊娠不良结局以及新生儿低血糖的发生率随HbAlc水平的升高而升高，不同HbAlc水平（≤6.0%；>6.0%~6.5%；>6.5%~7.0%；>7.0%）患者的不良妊娠结局以及新生儿低血糖发生率差异有统计学意义（P<0.05）；两组患者胎膜早破发生率差异无统计学意义（P>0.05），且两组患者胎膜早破发生率与HbAlc水平无相关性（P>0.05）。结论 HbAlc水平与妊娠期糖尿病患者不良结局相关，应加强HbAlc水平检测并严格监控以降低不良妊娠结局发生率，为母婴安全提供保障。 |
| 英文摘要: |
| Objective To explore the relationship of glycated hemoglobin (HbAlc) levels and adverse pregnancy outcomes in the patients with gestational diabetes mellitus (GDM).Methods 120 cases of GDM patients ever treated in our hospital from Jan 2014 to May 2015 were randomly selected as the study group, and other 120 healthy gravidas were selected as the control group.The levels of HbAlc and blood glucose in the study group were strictly monitored and followed up till termination of pregnancy.The HbAlc levels, incidences of adverse pregnancy outcomes such as premature birth, polyhydramnios, fetal macrosomia and premature rupture of fetal membranes, together with incidence of neonatal hypoglycemia, in the study group were recorded.Results The incidences of neonatal hypoglycemia and such adverse pregnancy outcomes as premature birth, polyhydramnios, fetal macrosomia and fetal distress in the study group were higher than those in the control group, and their differences were all statistically significant (all P<0.05).The incidences of adverse pregnancy outcomes and neonatal hypoglycemia in the study group increased with the increment of HbAlc levels, and these incidence differences at different HbAlc levels (≤6.0%; 6.0% 6.5%; 6.5% 7.0%; >7.0%) were also significant (all P<0.05).But there was no significant difference in the incidence of premature rupture of fetal membranes between the two groups (P>0.05), and the incidences of both groups were uncorrelated with their HbAlc levels.Conclusion The HbAlc levels of GDM patients are in relation to their adverse pregnancy outcomes, and should be detected and monitored sensitively so as to reduce the occurrence of adverse outcomes and ensure the safety of infants and gravidas. |
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