| Objective To investigate the efficacy of prophylactic administration of carbetocin on the postpartum hemorrhage in the high-risk puerperae with vaginal delivery.Methods 240 puerperae with high-risk factor of uterine atony after vaginal delivery, ever delivered in our hospital from Jan 2015 to Mar 2016, were selected and randomly divided into the carbetocin group and the control group, 120 cases in each group.The puerperae in the carbetocin group were given 100 μg caebetocin via intravenous injection right after delivery of fetus, while the puerperae in the control group were given 20 IU oxytocin via intramuscular injection.Between the high-risk puerperae of two groups, their 2-hour postpartum bleeding volume, uterine contraction situation, occurrence of need for additional treatment, and changes in the blood routine examination and vital signs were compared.Results Compared to the control group, the caebetocin group had less 2-hour postpartum bleeding volume, better rate of good uterine contraction, lower occurrence of need for additional treatment, and smaller decline in the red blood cell and hemoglobin levels, with statistically significant differences between them (all P<0.05).But there was no significant difference in the 2-hour postpartum systolic blood pressure, diastolic blood pressure, heart rate, blood oxygen saturation and respiratory rate between the two groups (P>0.05).Conclusion Prophylactic administration of carbetocin in the high-risk puerperae with vaginal delivery could effectively strengthen the uterine contraction, reduce the postpartum bleeding volume, and is worthy of clinical promotion. |
