| Objective To hypothesize the correlation between damage of coronary artery and dysfunction of autonomic nervous system by HRV among subjects with stable angina.Methods A total of 118 subjects diagnosed as stable angina pectoris by elective coronary angiography were divided into two groups by Gensini score system (GS):GS≤32 (GS1) and GS2>32 (GS2). Subgroups were divided based on location of stenosis lesions and the number of coronary artery disease. Another 86 subjects suspicious with stable angina pectoris with normal coronary angiography were selected as the control group. All subjects received 24-hour ambulatory electrocardiogram and the result of time-domain HRV was analyzed (SDNN, SDANN, SDNNind, RMSSD, PNN50).Results Compared with control group, SDNN, SDNNind and RMSSD were lower in GS1, and SDNN, SDANN, SDNNind, RMSSD, PNN50 were lower in GS2(P<0.05); compared with GS1, SDNN was lower in GS2(P<0.05). Compared with control group, SDNN in one-vessel, SDNN, SDANN in two-vessel diseased and in three-vessel diseased were lower(P<0.05), and compared with two-vessel diseased, SDNN and SDANN were lower in three-vessel diseased(P<0.05). Compared with right-coronary artery diseased, SDNN and SDANN in left-coronary artery diseased group were lower(P<0.05), while compared with lesions in left circumflex, SDNN in lesions in left anterior descending artery was lower(P<0.05).Conclusion HRV reveals the severity of damage of coronary artery, which plays a crucial role in the prediction of dysfunction of autonomic nerve system. |
