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| 射频消融治疗结直肠癌肝转移的回顾性研究 |
| Retrospective study of radiofrequency ablation for colorectal carcinoma combined with liver metastasisWANG Zhanggui, |
| 投稿时间：2016-03-14 |
| DOI：10.3969/j.issn.1000-0399.2016.12.009 |
| 中文关键词: 结直肠癌 肝转移 射频消融 |
| 英文关键词: Colorectal carcinoma Liver metastases Radiofrequency ablation |
| 基金项目:浙江省重大科技专项重点社会发展项目（项目编号：2010C13025） |
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| 中文摘要: |
| 目的 探讨射频消融（RFA）治疗结直肠癌肝转移的预后及影响因素。方法 回顾性分析2003年3月至2013年8月浙江大学附属邵逸夫医院肿瘤内科30例经RFA治疗的结直肠癌肝转移患者的临床及随访资料。结果 30例患者中，结肠癌患者18例，直肠癌患者12例。治疗后射频病灶复发1例（3.3%），肝内复发12例（40.0%），肝外复发11例（36.7%）。术后接受化疗20例（66.7%），中位无进展生存（PFS）为6.6个月，总生存（OS）为25.5个月；未接受化疗10例（33.3%），中位PFS为3.7个月，OS为22.5个月。不同转移时机、病灶大小及术后化疗与否患者PFS、OS的差异有统计学意义（P<0.05）。结论 RFA是结直肠癌肝转移患者一种安全、有效的局部治疗方法，病灶<3 cm、异时性转移及接受化疗的患者可以获得较长的PFS和OS。 |
| 英文摘要: |
| Objective To explore the prognosis and influential factor of radiofrequency ablation (RFA) for colorectal carcinoma combined with liver metastasis.Methods The clinical and follow up data of 30 patients who received RFA therapy were retrospectively analyzed.Results There were 18 cases with colon carcinoma and 12 cases with rectal carcinoma. The success rate was 96.7%.The local recurrence was 3.3%. The novel hepatic recurrence rate was 40.0%, and extra-hepatic recurrence rate was 36.7%. There were 20 cases (66.7%) who underwent chemotherapy and 10 cases (33.3%) without chemotherapy after RFA therapy. The median time of progression of free survival (PFS) was 6.6 months vs 3.7 months and the over survival (OS) was 25.5 months vs 22.5 months in chemotherapy groups and not after RFA therapy, respectively. Statistical analysis indicated that the occasions of metastases (metachronous or synchronous), size of lesions and chemotherapy (and or not) were significant predictors for PFS and OS.Conclusion RFA is a secure and effective local therapy for colorectal carcinoma combined with liver metastasis. Prolonged PFS and OS could be acquired in selective patients with size≤3cm, metachronous metastases and chemotherapy. |
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