| Objective To evaluate the concentrations of peripheral blood tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and soluble intercellular adhesion molecule-1(sICAM-1)in the serum of hand-foot-and-mouth disease(HFMD)children and their effects on the pathogenesis of HFMD.Methods The levels of TNF-α, IL-6, sICAM-1 in serum were determined before and after treatment with the method of ELISA,in 45 children who were admitted with severe HFMD and 42 children with mild HFMDand 25 children as normal controls.Results The levels of TNF-α, IL-6, sICAM-1 in serum before treatment were significantly higher than those in controls(P<0.05),TNF-α, IL-6, sICAM-1 levels in severe HFMD group were higher than those in the mild HFMD group(P<0.05);after treatment,the TNF-α, IL-6, sICAM-1 levels in severe HFMD were higher than those of control group(P<0.05),and the difference of TNF-α, IL-6, sICAM-1 between mild HFMD and control group had no statistical significance(P>0.05).Conclusion TNF-α, IL-6, sICAM-1 may contribute to the pathogenesis of HFMD,the increase is closely correlated with the severity of the injury,and TNF-α, IL-6, sICAM-1 may serve as markers in severity and prognosis of HFMD. |
