| Objective To investigate the clinical characteristics and curative effect,prognostic factors in non-small cell lung cancer (NSCLC) with malignant pleural effusion(MPE).Methods The data of 91 patients with malignant pleural effusion in non-small cell lung cancer were collected, including the patients'general clinical data(sex,age,histological type,the onset of tumor staging, the time of MPE,other effusion,and bilateral pleural effusion), details of pleural effusion(whether it was congestive pleural effusion,number of the effusion cells,LDH,CEA, and cytopathology of pleural effusion)and treatments of pleural effusion,and the factors which influenced pleural effusion control and survival time under the above conditions were analyzed.Results RR in congestive pleural effusion patients was 48.7%,which was significantly lower than that of non congestive patients with pleural effusion.The RR was 70.3% in local application of IL-2 chest biological treatment,significantly higher than that without the IL-2 biological treatment.The median overall survival of non congestive pleural effusion patients was 13 months,and that of local application of IL-2 chest biological treatment was 12 months.Adenocarcinoma of EGFR-TKI combined chemotherapy survived better than pure chemotherapy,and the latter was superior to the pure EGFR-TKI.Conclusion Congestive pleural effusion has bad curative effect and worse overall survival.Local application of IL-2 chest biological treatment has better effect and overall survivaladvantage. |
