| Objective Toobserve the clinical effect of nicorandil onangina patients with percutaneous coronary intervention,andexplore the effect of nicorandil onmalondialdehyde and adiponectin levels in patients with angina.Methods A total of 180 cases of angina patients with percutaneous coronary intervention received from January 2013 to January 2015 in Affiliated HospitaltoYan'an Universitywere randomly divided into two groups:the control group(90 cases)which received conventional therapy, and observation group(90 cases) which received conventional therapy.Results The effective rate in observation group(96.7%) was significantly higher than that in control group(81.1%) (P<0.05). After the treatment, the angina attack frequency in two groups decreased (P<0.05), but the observation group changed more significantly (P<0.05).The amount of nitroglycerin after treatment was significantly lower than before (P<0.05),and the amount in observational group was significantly lower thanthat in control group (P<0.05). After treatment, the levels of MDA, total cholesterol, triglyceride and low density lipoprotein were significantly lower than those before (P<0.05),and the indexes were significantly better thanthose in control group (P<0.05).The APN levels were significantlyincreased after treatment (P<0.05), and APN levelsin observation group were significantly higher than in control group (P<0.05).There were three cases of abdominal distension and nausea in the observation group and two cases of redness and headache in the control group, andthere was no significant difference between the two groups (P>0.05).Conclusion Angina patients with PCI treated with nicorandil can effectively improve the symptoms of angina, reduce myocardial injury and improve the prognosis. |
