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| 白细胞计数/平均血小板体积比值及中性粒细胞/淋巴细胞比值评估急性冠脉综合征患者介入治疗预后的价值 |
| Value of ratio of white blood cell to mean platelet volume and neutrophil to lymphocyte on predictingoutcome in acute coronary syndrome with primary percutaneous coronary intervention |
| 投稿时间：2016-04-20 |
| DOI：10.3969/j.issn.1000-0399.2017.01.009 |
| 中文关键词: 急性冠脉综合征 白细胞计数 平均血小板体积 中性粒细胞数 淋巴细胞 高敏C反应蛋白 |
| 英文关键词: Acute coronary syndrome White blood cellcount Mean platelet volume Neutrophil count Lymphocyte High-sensitive C reactive protein |
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| 中文摘要: |
| 目的 探讨白细胞计数与平均血小板体积之比（WMR）和中性粒细胞与淋巴细胞比值（NLR）对首次行经皮冠状动脉介入治疗（PCI）的急性冠脉综合征患者术后的短期预后评估价值。方法 连续入选2014年10月至2015年12月首次行急诊或择期PCI治疗患者104例。观察入院时的WMR和NLR与行介入术后6个月内发生主要不良心血管事件（MACE）的相关性。结果 WMR、NLR与高敏C反应蛋白（hs-CRP）呈正相关（r=0.623，P<0.05；r=0.575，P<0.05）；发生MACE事件组患者WMR、NLR、hs-CRP均高于未发生MACE事件组，差异均有统计学意义（P<0.05）。Kaplan-Meier生存分析显示高WMR（≥0.487）、高NLR（≥3.136））、高hs-CRP（≥7.515）患者MACE事件发生率明显升高。多因素分析显示，WMR（≥0.487），NLR（≥3.136）、hs-CRP（≥7.515）均为MACE事件的独立风险因素[OR=4.392，95% CI（1.338~14.423），P=0.015；OR=5.082，95% CI（1.276~16.241），P=0.021；OR=3.289，95% CI（1.067~10.134），P=0.038]。结论 WMR联合NLR对行首次介入治疗的ACS患者6个月内MACE事件有较高的预测价值，高WMR、NLR、hs-CRP均为MACE事件发生的独立风险因素。 |
| 英文摘要: |
| Objective To explore the value of the ratio of white blood cell to mean platelet volume(WMR) and neutrophil to lymphocyte (NLR)on predicting the short-term outcome in acute coronary syndrome with primary percutaneous coronary intervention(PPCI). Methods From October 2014 to December 2015, a total of 104 patients with acute coronary syndrome undergoing primary PPCIwere prospectively enrolled. The relationship between baseline WMR and NLR and major adverse cardiovascular events (MACE) incidence was assessed during a mean follow-up of 6 months. Results There was a significant correlation between WMR and hs-CRP(r=0.623, P<0.05). There was a significant correlation between NLR and hs-CRP(r=0.575, P<0.05);WMR, NLR and hs-CRP were significantly higher in MACE patients than in patients without MACE(P<0.05).Kaplan-Meier survival analysis showed that the incidence of MACE was significantly higher with high WMR ≥0.487,higher NLR(≥3.136) or hs-CRP(≥7.515).Multi-factor regression analysis indicated that WMR(≥0.487), NLR(≥3.136) and hs-CRP(≥7.515)were independent risk factors for the primary acute coronarysyndromeundergoing PPCI with MACE. Conclusion The elevated baseline WMR, NLR and hs-CRP are independent risk factors, which can predict the value for the MACE of primary acute coronary syndrome undergoing PPCI. |
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