| Objective To evaluate whether the pleiotropic effects of statins could reduce the occurrence of delirium.Methods The published randomized-controlled trials involved about whether or not statins use reducing risk of delirium were searched from such databases as PubMed, Wanfang, Cochrane library, EMBase, VIP and CNKI, dating from Jan 2000 to Jun 2016, with the searching words of delirium, ICU delirium, statin(s), simvastatin, atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, pravastatin, rosuvastatin and HMG-CoA reductase inhibitor(s). The collected literatures were strictly assessed by the Jadad scale, and the primary quality indicator was the efficacy of statins, with the secondary indicators of hospital stays and cases of mechanical ventilation. The systematic analysis was performed by software RevMan 5.2. Results There were 7 trials, 290274 participants included, which showed that taking statins was neither associated with the incidence rate of delirium (OR:1.01; 95%CI 0.81~1.26), nor associated with shorter hospital stays (WMD:1.93; 95%CI -5.62~9.47). However, statins use could reduce the cases of mechanical ventilation in the critical patients (OR:0.65; 95%CI 0.47~0.90). Conclusion Statins use could not reduce the occurrence of delirium. |
