| Objective To investigate the value of acute pancreatitis(AP) patients' peripheral blood alpha melanocyte stimulation hormone (α-MSH), trypsin peptide (TAP), interleukin 6 (IL-6) in evaluation of the severity of the patient condition.Methods A total of 97 patients with AP were selected in the Second Hospital of Anhui Medical Universityfrom June 2015to March 2016, and among them 56 patients were enrolled in mild group and 41 patients insevere group. The peripheral blood was collected in all patients on 1st, 3rd, 5th, 7th day of admission. Enzyme-linked immunosorbent assay was employed for quantitative determination of α-MSH, TAP, IL-6, and severe group was administered once APACHEⅡ and Ranson's score on admission.Results Compared with the mild group, the peripheral bloodα-MSH in the severe group was at a low level in one week, IL-6 was at a higher level, and the first three days of TAP were at a higher level, and the difference between thetwo groups was statistically significant (P<0.05). In the evaluation of disease severity, α-MSH the area under the curve was 0.848, Ranson score under the curve was 0.818, APACHE-II score under the curve was 0.789, TAP under the curve was 0.675, IL-6 under the curve was 0.693. α-MSH, and TAP and IL-6 combined under the curve was 0.906.Conclusion Peripheral bloodα-MSH, TAP, IL-6 levels have some clinical valuein predicting AP severity degree. The accuracy of α-MSH in evaluating the severity of the disease is higher than that of the TAP and IL-6. The combined use of the three in detection has higher accuracy. |
