| Objective To investigate the prognostic factors for survival in patients who had low grade gliomas harboring brain eloquent areas. Methods In this 5 years of study, 62 cases newly diagnosed as low grade gliomas harboring eloquent areas were retro-analyzed to seek prognostic factors affecting survival. Firstly, Kaplan-meier method was applied to analyze 11 related clinical factors such as age, gender, initial symptom, histological subtype, and so on. Then Cox multivariate regression analysis was used. Results Univariate analysis showed that patients with age <40 years, preoperative KPS≥70 points, total tumor resection, oligodendroglioma and postoperative chemotherapy combined with radiotherapy had longer progression-free survival (PFS) and overall survival (OS) thanthose patients whose age≥40 years, preoperative KPS score of <70 points, non-total cut, astrocytoma or mixed oligodendrocytomas, postoperative chemotherapy or radiotherapy alone, and the difference was statistically significant (P<0.05). Mutivariate analysis showed that age, preoperative KPS score, EOR, histological subtype were independent predictors in improving PFS and OS. Conclusion Patients with younger age, high preoperative KPS score, and low-grade gliomas with oligodendrocyte componets have better prognosis. Furthermore, surgical total resection and postoperative radio-chemotherapy could prolong the survival of patients. |
