| Objective To observe the effect of penehyclidime hydrochloride combined with preventive trachea intubation in treating severe acute organophosphosphorus pesticide poisoning. Methods The clinical data of 62 patients with severe acute organophosphosphorus pesticide poisoning admitted tothe Affiliated Chaohu HospitalofAnhui Medical University from January 2006 to August 2014were analyzed retrospectively. The patients were divided into two groups according to different treatment methods, 32 cases were treated by penehyclidime hydrochloride combined with preventive trachea intubationin (A group), and the other 30 cases by penhyclidime hydrochloride(B group). Their death rate, drug dose, incidence of aspiration and deliration, andICU average length of staywere observed and compared. Results There was no death in the A group, while the mortality rate of B group was 13.3%. The incidence of aspiration was 9.4% and 33.3%. The incidence of delirium in A group and B group was 21.9% and 46.7%, respectively, and the difference was statistically significant (P<0.05). The average length of hospital stay in A group and B group was (5.3±2.4) d (ICU), (6.2±2.5) d, respectively, and the difference was statistically significant (P<0.05). The total amount of penehyclidinehydrochloride drug in A group and B group was(16.9±3.2)mg, (18.4±3.9) mg, respectively, and there was no significant difference (P>0.05). Conclusion Penehyclidime hydrochloride combined with preventive trachea intubation in treating severe may reduce the death rate, incidence of aspiration and deliration, ICU average length of stay. |
