| Objective To investigate the changes of betatrophin levels and analyze the correlation between betatrophin and related indicators in the development of patients with gestational diabetes mellitus (GDM). Methods A total of cases among 24-32 weeks pregnant women were collected from March 2016 to August 2016 in the First Affiliated Hospital of Anhui Medical University. According to the diagnostic standards of GDM set by the IADPSG in 2010, pregnant women were divided into GDM group and normal glucose tolerance (NGT) group, with 60 pregnant women in each group. Then each group was divided into normal weight subgroup (GDM-NW, NGT-NW) and over weight subgroup (GDM-OW, NGT-OW) according to whether the body mass index (BMI) was greater than 24. Height, weight, blood lipid of all participants were measured; serum betatrophin levels were measured by ELISA; homeostasis model assessment of insulin resistance (HOMA-IR) and HOMA-beta-cell insulin secretion index (HOMA-beta) were calculated. The correlations between fasting serum betatrophin and pre-pregnancy BMI, fasting insulin, HOMA-IR, serum triglyceride were analyzed by linear regression analysis. Results The serum betatrophin levels were as follows:GDM-OW group:(2095.2±350.30)pg/ml; NGT-NW group:(1793.5±459.38)pg/ml; NGT-OW group:(1858.3±511.04)pg/ml. The serum betatrophin levels of GDM-OW group were higher than those of NGT-OW group, and the difference was statistically significant (P<0.05). The fasting serum betatrophin levels was found to be correlated positively with before pregnancy BMI, FINS, HOMA-IR and TG. Multiple stepwise regression analysis showed that TG was the influencing factor of serum betatrophin level. Conclusion Serum betatrophin levels are correlated with insulin resistance and lipid metabolism in gestational diabetes mellitus, and betatrophin takes part in the development of GDM especially in GDM-OW patients. |
