Objective To investigate and compare the influence of therapy regimens with pingyangmycin alone or pingyangmycin combined with dexamethasone on the curative effect and prognosis in the patients with superficial hemangiomas. Methods 360 cases of children with superficial hemangiomas, ever treated in our hospital from Jan 2014 to Jul 2015, were selected and divided into the study group and the control group by random number table method, 180 cases in each group. Additionally, patients in the study group were further divided into the capillary hemangiomas subgroup (68 cases), the cavernous hemangiomas subgroup (56 cases) and the mixed hemangiomas subgroup (56 cases) according to their clinical classification. According to the size of tumors, the study group was also divided into the subgroup of tumor area >2.5 cm2 (78 cases) and the subgroup of tumor area ≤2.5 cm2 (102 cases). The control group was given pingyangmycin treatment alone, while the study group was treated with pingyangmycin combined with dexamethasone. The clinical curative effects in the study group and the control group, and the curative effects in each subgroup based on clinical classification and tumor size, were compared respectively. The occurrence of adverse reactions in the two groups after treatment was recorded. Results The total effective rate of the study group was significantly higher than that of the control group (P<0.05), and the total effective rate of the capillary hemangiomas subgroup was also higher than that of the cavernous hemangiomas subgroup or the mixed hemangiomas subgroup, with significant differences (all P<0.05). Furthermore, the total effective rate of the subgroup of tumor area ≤2.5 cm2 was significantly higher than that of the subgroup of tumor area >2.5 cm2 (P<0.05). No significant difference was found in the complications between the two groups (P>0.05). Conclusion The therapy regimen of pingyangmycin in combination with dexamethasone could effectively improve the curative effects in children with superficial hemangiomas, especially in those with capillary hemangiomas, with better efficacy and higher safety, and is worthy of clinical application and expansion. |