| Objective To investigate the expression of apoptosis inhibitory factor (ARC) and its protective effects on caspase in mice with acute viral myocarditis (AVMC).Methods Sixty AVMC mice were randomly divided into ARC antisense oligonucleotides (group A), ARC missense oligonucleotide group (groupB) and normal saline control group (groupC), with 20 mice in each group. Peripheral blood specimens in different stageswere collected for determination of cardiac troponin T (cTnT), cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and the level of ARC, dynamin related protein 1 (Drp1) expression data. Results On 7th, 14th, and 21stdays after modeling, the difference in cTnT, cTnI, CK and CK-MB levels in the peripheral blood of the three groups was statistically significant (P<0.05), and group C was similar to groupB (P>0.05), but lower than that of groupA. On 7th day after modeling, difference in ARC and Drp1 protein expression level in three groups was statistically significant (P<0.05), ARC in group C was similar to that in group B(P>0.05), but higher than that in group A (P<0.05); the expression of Drp1 protein in groupC was similar to that in group B(P>0.05), but lower than that in group A(P<0.05). ARC and Drp1 protein expression level on 14th and 21stdays after the modeling in three groups showed no significant difference (P>0.05).Conclusion The high expression of AVMC can inhibit the apoptosis of myocardial cells and protect the myocardium after ARC. |
