| Objective To study the clinical, pathological features and misdiagnosis of the cutaneous mastocytosis(CM). Methods The clinical characteristics, histopathologic changes (HE and Giemsa staining) and misdiagnosed cases of 29 cases of CM were retrospectively analyzed. Results The age of the patients ranged from 40 days to 49 years. Sixteen patients were aged two years or younger. The clinical signs of CM were variant. There were 22 cases of maculopapular CM (MPCM) (75.86%), 3 cases of mastocytoma (10.35%), 4 cases of diffuse CM(DCM) (13.79%), respectively. Two patients suffered from bulla and one adult patient had telangiectasia macularis eruptiva perstans. There were 13(44.83%) cases of clinical misdiagnosis. Histologically, diffuse infiltration of the mast cells in the dermis was found in 13 cases, including 2 cases of subepidermal blister; 16 cases demonstrated subtle infiltration within the papillary dermis. Purple metachmmafic granules in mast cells were shown by Giemsa staining in all cases. Conclusion CM is more often seen in children, especially in infants with varied lesions. MPCM is the most common form. CM is prone to misdiagnosis, especially in adults. To reduce the misdiagnosis, doctors should strengthen the ability to identify atypical CM with help of the histopathologic examination and dye. |
