| Objective To investigate the effect of lanthanum carbonate on serum phosphorus removal in maintenance hemodialysis (MHD)patients. Methods Fifty patients who reveived maintenance hemodialysis(dialysis at least 6 months) at this hospital from January 2014 to December 2015 were selected for the study. They were randomly divided into lanthanum carbonate group (group LC) and calcium carbonate group (group CC) with 25 cases in each, and then the levels of serum phosphorus, calcium, parathormone(PTH) were compared after treatment for 4 weeks, 24 weeks respectively, as well as calcium, phosphorus, parathyroid hormone levels 24 weeks after treatment. Results Forty-seven patients completed the survey. Compared with those before treatment, the levels of serum phosphorus in LC group and CC group all decreased after 4 weeks treatment (P<0.05); compared with that before treatment, the level of serum phosphate in LC group decreased significantly after 24 weeks treatment (P<0.05), and the level of serum phosphate in CC group decreased significantly after 24 weeks treatment (P<0.05); the serum calcium in LC group did not significantly increase during the whole treatment; however, the serum calcium increased in CC group after 24 weeks treatment, and the difference was statistically significant (P<0.05); the level of PTH in both groups decreased, and the difference was statistically significant (P<0.05). After 24 weeks, the levels of serum phosphate, serum calcium and PTH in LC group were markedly lower than those in CC group (P<0.05). Conclusion Lanthanum carbonate could decrease the levels of serum phosphorus safely and effectively in ESRD patients. |
