| Objective To investigate the changes and significance of serum NSE and VILIP-1 in hypoxic-ischemic encephalopathy.Methods A total of 136 cases of children with HIE were selected from March 2012 to April 2015 in Zhengzhou City Children's Hospital and were divided into mild (n=58), moderate (n=46) and severe (n=32), according to the condition of patients. At the same time, 45 cases of normal newborns were selected as the control group. The serum levels of NSE and VILIP-1 in HIE children after born (T0), 48 h(T1), 72h (T2) and 7 d (T3), and in control group, at T0,were respectivelydetected. The NBNA scores were evaluated at birth 24 h in HIE children and control group. Results The serum levels of NSE and VILIP-1 in HIE children at T0 were (28.82±6.34)μg/L,(0.91±0.26)μg/L, respectively, which were higher than the control group[(13.94±2.82)μg/L, (0.38±0.15)μg/L], while the NBNA score[(33.83±2.25) point] was lower than that of the control group[(38.24±2.41) point], andthe differences were statistically significant (P<0.05). Pearson correlation analysis showed, at T0, the serum level of NSE in HIE children was positively correlated with the level of VILIP-1 (r=0.612, P<0.05), while the serum levels of NSE and VILIP-1 were negatively correlated with NBNA scores (r=-0.481 and -0.440, P<0.05). Compared with mild, the serum levels of NSEand VILIP-1 at T0~3 in moderate and severe increased, and were higher in severethan in the moderate, and the differences were statistically significant (P<0.05).Conclusion The serum levels of NSE and VILIP-1 in HIE children are elevated. It is of great significance for dynamic monitoring of serum levels of NSE and VILIP-1 in early diagnosis, condition determination and treatment assessmentof HIE. |
