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| 25-羟维生素D水平与肾癌发病的相关性分析 |
| Correlation analysis of serum 25-hydroxyvitamin D levels withrisk of renal carcinoma |
| 投稿时间：2017-08-24 |
| DOI：10.3969/j.issn.1000-0399.2017.11.007 |
| 中文关键词: 肾癌 25-羟维生素D 危险因素 logistic回归 |
| 英文关键词: Kidney cancer 25-hydroxyvitamin D Risk factor Logistic aggressionanalysis |
| 基金项目:安徽省自然科学基金（项目编号：1608085QH173），安徽医科大学校科研基金（项目编号：2017xkj036），安徽医科大学校科研基金（项目编号：2015xkj025） |
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| 中文摘要: |
| 目的 探讨25-羟维生素D水平与肾癌发病的关系。方法 选取2015年3月至2017年8月安徽医科大学第二附属医院收治的初治肾癌患者100例设为肾癌组,同期选择本院体检者采用倾向性评分法匹配200例非肿瘤人群为对照组,检测两组人群25-羟维生素D水平,比较两组患者的一般临床资料、实验室检查（如血钠、血磷、血钙及血肌酐）及25-羟维生素D水平等资料。采用单因素分析与因变量相关的变量,将有统计学意义的变量纳入多因素二分类logistic回归中再次分析。结果 25-羟维生素D （B=-0.067,OR=0.935,P=0.001）及高血压（B=0.064,OR=1.896,P=0.001）是影响肾癌发病的独立危险因素。结论 高水平的25-羟维生素D是肾癌的保护因素。 |
| 英文摘要: |
| Objective To study the relationship between serum levels of 25-hydroxyvitamin D and therisk of kidney cancer. Methods 100cases of untreatedpatients with kidney cancer,admitted in our hospital from Mar 2015 to Aug 2017,were enrolled as the carcinoma group. And by means of propensity score matching, other 200 cancer-free people diagnosedby our medical examinerswere assigned simultaneously to the control group. Afterdetection ofserum 25-hydroxyvitamin D levels in all subjects, differences in the general clinical data, laboratory indexes (including serumlevels of sodium, phosphorus, calcium and creatinine) and 25-hydroxyvitamin D levels between the two groups werecompared. By univariate analysis, thosestatisticallysignificant variables associated with the dependent variables were identified and brought intomultivariatebinarylogistic regression forfurther analysis. Results The 25-hydroxyvitamin D level(OR=0.935, P=0.001)and hypertension(OR=1.896, P=0.001)were independent risk factors ofrenal carcinoma. Conclusion Higher level of25-hydroxyvitamin D mightbe aprotective factorof kidney cancer. |
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