| Objective To observe the efficacy and safetyof fluvastatin sustained-release tablets in the treatment of dyslipidemia in patients with hypertension. Methods A total of 120 patients of dyslipidemia with mild to moderate hypertension were selected, who were treated with fluvastatin sustained-release tablets 80mg once every night for a follow-up of 12 weeks, then 115 of them were recruited in statistical analysis. Blood lipid, high sensitive C reactive protein (hs-CRP), as well as 24 h ambulatory blood pressure parameters were measured before and after treatment. The change of low density lipoprotein cholesterol was compared and analysed in correlation with the dynamic blood pressure change.Results Compared with before treatment, the serum triglycerides(TG),total cholesterol(TC)[(5.40±0.85)mmol/L vs (4.10±0.95)mmol/L], low density lipoprotein cholesterol(LDL-C)[(3.58±0.61)mmol/L vs(2.49±0.64)mmol/L]decreased after treatment; meanwhile, non-high density lipoprotein cholesterol (nonHDL-C),24 h average pulse pressure (24 hMAP)[(104.96±10.98)mmHg vs (97.4±9.88)mmHg],daytime systolic blood pressure variability (dSBPV)[(17.3±4.08)mmHg vs (14.3±5.09)mmHg],nightime systolic blood pressure variability (dDBPV)[(15.50±4.08)mmHg vs (12.89±8.09) mmHg],hs-CRP level[(2.65±10.55)mg/L vs (4.45±8.61)mg/L]were all lower with statistical significance (P<0.05);high density lipoprotein cholesterol(HDL-C) level after treatment was significantly higher (P<0.05). However, glutamic pyruvic transaminase(ALT),aspartate aminotransferase (AST) had no significant difference(P>0.05).To some degree,the changes of LDL-C amplitude were influenced by the changes of 24 hMAP, dSBPV, dDBPV.Conclusion Fluvastatin has reliable curative effect and good safety in lowering lipid,at the same time it can be anti-inflammatory, involved in blood pressure rhythm adjustment. |
