| Objective To investigate the effects of laparoscopic cholecystectomy on serum cytokines and oxidative stress response in those patients with chronic cholecystitis and gallbladder stones.Methods Eighty-four patients with chronic cholecystitis and cholecystolithiasis treated in our hospital between Dec 2015 and Feb 2017 were collected, and then divided into the study group and the control group by means ofrandom number table, 42 cases in each group. Patients in the control group under went mini-incision cholecystectomy, and the study group was treated with laparoscopic cholecystectomy. These rum levels of inflammatory factors, immunoglobulin, T lymphocyte subsets, liver function and oxidative stress before operationand 1 day after operationwere detected and compared between the two groups.Results After surgery, the serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the study group were significantly lower than those in the control group (P<0.05). The falling ranges after operation of immunoglobulin IgA, IgG and IgM, and T lymphocyte subsets CD4+, CD8+ and CD4+/CD8+ in the study group were significantly lower than those in the control group(P<0.05). Compared with the control group, the rising ranges after operation of malonaldehyde(MDA) and the falling ranges after operation of superoxide dismutase(SOD) and reduced glutathione peroxidase(GSH-Px)in the study group were much lower,and differences between the two groups were statistically significant (P<0.05). The levels of total bilirubin (TBIL), glutamyl transpeptidase(GGT), aspartate transaminase(AST) and alanine transaminase(ALT) in the study group were significantly lower than those in the control group (P<0.05).Conclusion Compared with mini-incision cholecystectomy, laparoscopic cholecystectomy has less effects on the patients'inflammatory response, immune function and oxidative stress, and would not easily damage the patients' liver function, so it is worthy of clinical recommendation. |
