文章摘要
银杏叶片阿司匹林肠溶片及阿托伐他汀钙片联用对脑梗死恢复期患者的临床疗效
Clinical efficacy of combinations of ginkgo leaf and atorvastatin calcium and aspirin enteric-coated tablets on patients in recovery period of cerebral infarction
投稿时间:2017-10-26  
DOI:10.3969/j.issn.1000-0399.2018.02.013
中文关键词: 银杏叶片  阿司匹林肠溶片  阿托伐他汀钙片  脑梗死恢复期
英文关键词: Ginkgo leaf tablets  Aspirin enteric-coated tablets  Atorvastatin calcium tablets  Recovery period of cerebral infarction
基金项目:
作者单位
蒋玉兰 617067 四川省攀枝花市中心医院药学部 
王相明 617067 四川省攀枝花市中心医院神经内科 
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中文摘要:
      目的 观察银杏叶片、阿司匹林肠溶片及阿托伐他汀钙片三药联用对脑梗死恢复期患者的临床疗效。方法 选取攀枝花市中心医院2015年1月至2016年12月收治的80例脑梗死恢复期患者为研究对象,按随机数字表法分为对照组和观察组,各40例。对照组给予阿司匹林肠溶片联合阿托伐他汀钙片的用药方案,观察组在对照组治疗基础上再给予银杏叶片。比较两组患者治疗6个月后血脂、血同型半胱氨酸水平和颈动脉内膜中层厚度及治疗总有效率。结果 治疗后两组患者总胆固醇、三酰甘油和低密度脂蛋白值比较,差异均无统计学意义(P>0.05);观察组高密度脂蛋白水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗6个月后,血同型半胱氨酸和颈动脉内膜中层厚度大于对照组,差异有统计学意义(P<0.05)。观察组的治疗总有效率为90.00%,高于对照组的72.50%,差异有统计学意义(χ2=4.021,P=0.045)。结论 银杏叶片、阿司匹林肠溶片和阿托伐他汀钙片三药联用可使脑梗死恢复期患者高密度脂蛋白水平升高,血同型半胱氨酸水平降低,颈动脉内膜中层厚度降低,减缓粥样斑块的进程,值得推广应用。
英文摘要:
      Objective To observe the clinical effect of drug combination of ginkgo leaf tablets and aspirin enteric-coated tablets and atorvastatin calcium tablets on those patients in recovery period of cerebral infarction.Methods 80 cases of patients in recovery period of cerebral infarction ever treated in our hospital from Jan 2015 to Dec 2016 were selected as the research objectives. Then they were divided into the control group and the study group by means of random number table, with 40 cases in each group. The control group received medications of aspirin enteric-coated tablets and atorvastatin calcium tablets, while the study group was treated with additional ginkgo leaf tablets on the basis of medications in the control group. The blood levels of lipids and homocysteine, carotid intima-media thickness (IMT) before and after treatment, together with total effective rate between the two groups were compared.Results After treatment, there was no significant difference in the levels of total cholesterol, triglycerides and low-density lipoprotein between the two groups (P>0.05), but the level of high-density lipoprotein in the study group was significantly higher than that in the control group (P<0.05). And at 6 months after treatment, the blood homocysteine level and carotid IMT in the study group were significantly higher than those in the control group (P<0.05).The total effective rate in the study group was 90.00%, which was much higher than that in the control group (72.50%), with statistically significant difference between them (χ2=4.021, P=0.045).Conclusion For those patients in recovery period of cerebral infarction, combined use of ginkgo leaf tablets and aspirin enteric-coated tablets and atorvastatin calcium tablets could increase the high-density lipoprotein level and decrease the homocysteine level, and reduce the carotid IMT to slow down development of atheromatous plaque, so it is worthy of promotion and application.
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