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| 血清同型半胱氨酸胱抑素维生素B6及炎症因子在糖尿病肾脏病中的临床意义 |
| The clinical value of serum homocysteine CysC vitamin B6 and inflammatory cytokines in diabetic kidney disease |
| 投稿时间：2017-08-02 |
| DOI：10.3969/j.issn.1000-0399.2018.03.008 |
| 中文关键词: 维生素B6 白介素6 肿瘤坏死因子α 同型半胱氨酸 糖尿病肾病 |
| 英文关键词: Vitamin B6 Interleukin-6 Tumor necrosis factor-alpha Homocysteine Diabetes nephropathy |
| 基金项目:国家高技术研究发展计划（863计划）（项目编号：2014AA022304） |
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| 摘要点击次数: 1889 |
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| 中文摘要: |
| 目的 探讨血清同型半胱氨酸（Hcy）、胱抑素C（Cys-C）、维生素B6（Vit B6）、白介素6（IL-6）、肿瘤坏死因子α（TNF-α）与糖尿病肾脏病（DKD）的相关性，分析DKD的相关危险因素。方法 收集2015年3月至2016年1月皖北煤电集团总医院肾内科及内分泌科收治的2型糖尿病患者80例，根据24 h尿白蛋白排泄率分为非DKD组（19例）和DKD组（61例）。酶联免疫吸附法统一检测血清IL-6、TNF-α、Vit B6水平。受试者工作特征曲线（ROC）分析Cys-C对DKD的诊断价值，Spearman相关分析检验各指标与DKD患者Cys-C和Hcy的相关性，DKD患者的Hcy和Cys-C相关分析采用多元线性回归分析。结果 Cys-C的ROC曲线下面积为0.77（P<0.05），灵敏度为57.38%，特异度为84.21%，尿酸（SUA）、24 h尿白蛋白与DKD患者的Cys-C水平呈正相关（rs=0.531、0.515，P<0.05），Vit B6、SUA与DKD患者Hcy水平呈正相关（rs=0.342、0.289，P<0.05）。多元线性回归分析显示，SUA、24 h尿白蛋白、Hcy与Cys-C呈正相关性（P<0.05）。结论 Cys-C对DKD有诊断价值，SUA、尿白蛋白、Hcy参与DKD发生发展，Vit B6通过降低Hcy对DKD起到保护作用。 |
| 英文摘要: |
| Objective To detect the correlation between concentrations of serum vitamin B6, Hcy, IL-6, TNF-α and diabetic kidney disease and explore the risk factors in diabetic kidney disease. Methods Eighty patients with type 2 diabetes entered the study from March 2015 to Jan 2016 in this hospital. We conducted a case-control study among among 19 non-DKD patients and 61 DKD patients according to their 24 h urinary albumin excretion.Vitamin B6,TNF-α,IL-6 were measured using ELISA.The diagnostic value of Cys-C was evaluated using receiver operating characteristic curve (ROC). Spearman Rank Correlation wasemployedto examine theassociation between Cys-C Hcy and other data. Multivariable linear regression modelswere used to examine the association between Cys-C and Hcy in DKD patients. Results In ROC Curve the area under the curve of Cys-C was 0.77(P<0.05), the sensitivity was 57.38%,and thespecificity was 84.21%. SUA and 24 h proteinuria(rs=0.531,0.515, P<0.05)were positively correlated with Cys-C.Vitamin B6 SUA(rs=0.342,0.289, P<0.05) waspositively correlated with Hcy. Multivariable linear regression showed that SUA Hcy and proteinuria were positively correlated with Cys-C(P<0.05). Conclusion Cys-C has predictive function on diabetic nephropathy.SUA proteinuria and Hcy play a role inthe pathogenesis and progression of diabetic nephropathy. Vitamin B6 has protective effect on DKD. |
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