Objective To explore the effects of intravenous atosiban combined with intrauterine human chorionic gonadotropin (hCG) injections on pregnancy outcomes in those infertility women. Methods 121 infertility women underwent more than once failed embryo implantation in our reproductive center between Jan 2015 and Feb 2017 were collected, and then divided into three groups by means of random number table. Group A (39 cases) received 45 cycles of frozen-thawed embryo transfer (FET) after intrauterine hCG injection, group B (40 cases) received 44 cycles of FET after intravenous atosiban injection, and group C (42 cases) received 45 cycles of FET after intrauterine atosiban combined with intrauterine hCG injections. The rates of clinical pregnancy, multiple pregnancy, implantation, abortion, ectopic pregnancy and live delivery were compared among the three groups. Results There were significant differences in the embryo implantation rate and live delivery rate among the patients of these groups (P<0.05). The embryo implantation rate in group C (43.53%) was higher than those in group A (21.84%) and group B (31.76%), and it was significantly different from that in group A (χ2=9.212, P=0.002), but was not significantly different from that in group B (χ2=2.506, P=0.113). The live delivery rate in group C (57.78%) was higher than those in group A (28.89%) and group B (45.45%), and there was significant difference when compared with group A (χ2=7.647, P=0.006), but there was no significant difference in comparison with group B (χ2=1.353, P=0.245). Conclusion Application of intravenous atosiban and intrauterine hCG injections before FET in those infertility women with failed FET could improve the embryo implantation rate and live delivery rate. |