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| IMA与SCUBE1联合检测在急性肺栓塞诊断中的价值 |
| Value of combined detection of IMA and SCUBE1 indiagnosis of acute pulmonary embolism |
| 投稿时间：2017-12-04 |
| DOI：10.3969/j.issn.1000-0399.2018.06.009 |
| 中文关键词: 缺血修饰性白蛋白 新型血小板活化蛋白血浆内皮生长因子样单链蛋白1相关补体Clr/Cls单肽 急性肺栓塞 |
| 英文关键词: Ischemia modified albumin Signal peptide-CUB-EGF domain-containing protein-1 Acute pulmonary embolism |
| 基金项目:邢台市卫生和计划生育委员会科研基金（项目编号：2015ZC221） |
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| 中文摘要: |
| 目的 探讨联合检测缺血修饰性白蛋白（IMA）与新型血小板活化蛋白血浆内皮生长因子样单链蛋白1相关补体Clr/Cls单肽（SCUBE1）在急性肺栓塞（APE）诊断中的价值。方法 收集2013年6月至2017年3月邢台市第三医院呼吸科就诊的APE患者130例为病例组；同时选取同期健康体检者为对照组（48例）。比较分析病例组和对照组血清中IMA和血浆中SCUBE1的水平，并用ROC曲线分析IMA、SCUBE1指标单独和联合应用对诊断APE的价值。结果 病例组患者IMA和SCUBE1水平均高于对照组，差异有统计学意义（P<0.05）。IMA单独诊断APE的敏感度和特异度分别为66.92%、77.08%；SCUBE1单独诊断APE的敏感度、特异度分别为67.69%与72.91%；IMA与SCUBE1联合检测诊断APE的敏感度、特异度分别为76.92%和85.42%。IMA、SCUBE1指标单独及联合应用诊断APE的ROC曲线的曲线下面积分别为0.796、0.839和0.888。结论 血清IMA和血浆SCUBE1均可作为诊断APE的生物标志物，在APE诊断中具有重要价值，同时检测二者有利于APE的诊治。 |
| 英文摘要: |
| Objective To assess the value of combined detection of ischemia modified albumin (IMA) and signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) in the diagnosis of acute pulmonary embolism (APE).Methods This study was based on the samples of 130 patients with APE (including 76 male and 54 female) and 48 healthy individuals. The levels of serum IMA and plasma SCUBE1 were detected and compared. Diagnostic efficacy of IMA, SCUBE1 and IMA + SCUBE1 was assessed by ROC curves.Results The levels of serum IMA and plasma SCUBE1 were significantly higher in APE patients than those in healthy individuals (P< 0.05). The sensitivity and specificity prediction for IMA were 66.92% and 77.08%, respectively. The sensitivity and specificity prediction for SCUBE1 were 67.69% and 72.91%, respectively.The sensitivity and specificity prediction for IMA + SCUBE1 were 76.92% and 85.42%, respectively. The area under the ROC curve (AUC) of IMA, SCUBE1 and IMA + SCUBE1 was 0.7958, 0.8387 and 0.8877, respectively.Conclusion IMA and SCUBE1 can be used in the diagnosis of APE. Combined detection of IMA and SCUBE1 contribute to the diagnosis of APE. |
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