| Objective To investigate the concentration changes and clinical significance of plasma total cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), apolipoprotein A1 (Apo-A1) and apolipoprotein B (Apo-B) in nephrotic syndrome (NS) patients.Methods Clinical data werecollected from January 2013 to November 2016 in Taihe People's Hospital. The subjectincluded 60 NS patients in disease group, 30 patients with kidney disease (non-nephrotic syndrome) in disease control group, and50 healthy onesin normal control group. The levels of CHOL, TG, HDL, LDL, Apo-A1 and Apo-B in three groups were detected and compared.Results CHOL,TG,HDL,LDL, Apo-A1 and Apo-B levels in NS patients were (9.18±2.50)mmol/L,(3.00±1.55)mmol/L,(1.65±0.53)mmol/L,(5.83±2.27)mmol/L,(1.66±0.42) g/L and (1.83±0.61)g/L, respectively. CHOL,TG,HDL,LDL,Apo-A1 and Apo-B levels in disease controls were (4.22±0.98)mmol/L,(1.89±1.35)mmol/L,(1.13±0.44)mmol/L,(2.39±0.70)mmol/L,(1.06±0.32)g/L and (0.88±0.22)g/L, respectively. In healthy controls, CHOL,TG,HDL,LDL,Apo-A1 and Apo-B levels were(4.42±0.46) mmol/l,(1.10±0.31) mmol/L,(1.33±0.21)mmol/L,(2.37±0.43)mmol/L,(1.31±0.17)g/L and(0.80±0.12)g/L, respectively. The biochemical indexes of the three groups were statistically significant(P<0.05). The levels of TG,HDL and Apo-A1 between disease control group and normal control group were statistically significant(P<0.05). The abnormal rate difference of CHOL, TG, HDL,LDL, Apo-A1 and Apo-B among the three groups was statistically significant(P<0.05).Conclusion Compared with normal health people and patients with non-NS nephropathy, there is a significant increase in blood lipids in NS patients. |
