| Objective To explore the distribution of elastic fiber in lung adenocarcinoma and its relationship with clinical features and prognosis.Methods 123 cases of lung adenocarcinoma conducted between January 2012 and August 2014.All of the samples dyed in hematoxylin-eosin(HE) and EF.According to the distribution of elastic fiber in lung adenocarcinoma,all cases were categorized into three elastic fiber patterns:EFP I,EFP Ⅱ,EFP Ⅲ. Then analyzed its relationship with clinical characteristics and prognosis of lung adenocarcinoma.The follow-up time was 5~66 moths.Results In 123 cases of lung adenocarcinoma, Inclouding 60(48.78%),23(18.70%),40(32.52%) cases presenting as EFP I,EFP Ⅱ,EFP Ⅲ.Single factor analysis showed:the elastic fiber grading in lung adenocarcinoma was no significant difference with the patient's age and sex(P > 0.05),but was correlated with tumor diameter,lymph node staging and pathological type(P < 0.05).(2)The follow-up results showed that:In 123 cases of lung adenocarcinoma,the overall survival rate of patients with EFP Ⅲ was significantly higher than EFP I and EFP Ⅱ.Three different levels in the EF survival rate was EFP I(60.00%),EFP Ⅱ(79.30%),EFP Ⅲ(95.00%),showing significant differences(P < 0.05).According to multiply factors analysis,the diameter of tumor and lymph gland were the independent factor which affect adenocarcinoma of lung(P < 0.05). But elastic fiber was not associated with prognosis(P > 0.05).Conclusion The prognosis of patients with obvious proliferation of EF is better,but EF hyperplasia is not an independent risk factor for prognosis. |
