| Objective To investigate the possibility of platelet-to-lymphocyte ratio (PLR) as a biomarker for carotid atherosclerosis in elderly patients with type 2 diabetes (T2DM). Methods From Jun 2015 to Jun 2017, 220 elderly patients with T2DM hospitalized in our hospital were enrolled in the study and divided into two groups:patients without carotid atherosclerosis were the normal group (n=118), and those with carotid atherosclerosis the atherosclerosis group (n=102). The lymphocyte, platelet, lipid and glucose in these individuals were determined and compared. And the correlation between PLR and carotid atherosclerosis was performed by Pearson analysis and logistic regression analysis. Results Compared with normal group, age, systolic pressure, PLT, PLR, LDL-C, TC, FBG, HbA1c and CIM T were higher in atherosclerosis group, while LC was lower (P<0.05). CIMT was positively correlated with age, systolic pressure, PLR, LDL-C, TC, FBG and HbA1c(P<0.05). In multiple linear regression analyses, after adjustment for age, lipid, glucose and so on, PLR was also positively correlated with CIMT. Logistic multiple regression analysis showed that after adjustment for risk factors, PLR was the independent variable for predicting carotid atherosclerosis in elderly patients with T2DM. According to the analysis of ROC curve, the cut off value of carotid atherosclerosis was set at 100.12, with the sensitivity of 79.80% and the specificity of 65.10%.Conclusion PLR is an independent risk factor for carotid atherosclerosis in elderly patients with T2DM. |
