| Objective To analys is risk factors in elderly patients with osteoporosis induced by glucocorticoid impact after renal transplantation. Methods Forty-three elderly patients with osteoporosis after renal transplantation treated in Zhengzhou Seventh People's Hospital from Feb 2015 to Feb 2017 were selected as observation group, meanwhile, 21 elderly patients without osteoporosis after renal transplantation were recruited as control group. The changes of bone density, serum oxidative stress indexes and inflammatory factors in two groups were observed, and the correlations between bone density with serum oxidative stress, inflammatory factors and the risk factors of osteoporosis were also analyzed. Results The bone density level in observation group was significantly lower than that in control group (P<0.05); the levels of advanced oxidation protein products (AOPP) and malondialdehyde (MDA) in observation group were significantly higher than those in control group, superoxide dismutase (SOD) and total antioxidant capacity (TAC) were significantly lower than those in control group, and the differences were statistically significant (P<0.05); the C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in observation group were significantly higher than those in control group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that BMD was positively correlated with SOD and TAC (r=0.531/0.474) and negatively correlated with AOPP, MDA, CRP, TNF-α and IL-6 (-0.592/-0.486/-0.327/-0.421/-0.307, all P<0.05). Logistic regression analysis showed age, AOPP, MDA, SOD, TAC, CRP, TNF-α and IL-6 were risk factors for osteoporosis (P<0.05). Conclusion Bone mineral density is negatively correlated with AOPP, CRP, TNF-α and IL-6 in elderly patients with osteoporosis induced by glucocorticoid shock after renal transplantation, and age, AOPP, MDA, SOD, TAC, CRP, TNF-α and IL-6 are all risk factors of osteoporosis. |
