文章摘要
亚临床甲状腺功能减退与甲状腺功能减退患者心脏结构及功能的改变
Changes of cardiac structure and function inpatients with subclinical hypothyroidism and hypothyroidism
投稿时间：2018-04-11  
DOI：10.3969/j.issn.1000-0399.2018.12.001
中文关键词: 亚临床甲状腺功能减退  甲状腺功能减退  左心室功能  超声心动图
英文关键词: Subclinical hypothyroidism  Hypothyroidism  Left ventricular function  Echocardiogram
基金项目:国家自然科学基金项目（项目编号：81300148）；首都医科大学基础临床联合项目（项目编号：JL201704）
作者单位E-mail
牛升梅 100020 首都医科大学附属北京朝阳医院心脏中心  
石慧丽 100020 首都医科大学附属北京朝阳医院心脏中心  
钟光珍 100020 首都医科大学附属北京朝阳医院心脏中心 zhongguangzhen@hotmail.com 
杨梅 100020 首都医科大学附属北京朝阳医院心脏中心  
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中文摘要:
      目的 观察亚临床甲状腺功能减退（SCH）和甲状腺功能减退（甲减）患者的超声心动图，分析其心脏结构与功能的改变。方法 选取2011年3月至2017年3月北京朝阳医院收治的58例SCH患者为SCH组，21例甲减患者为甲减组，选择同期甲状腺功能正常的健康体检者65例为对照组进行回顾性研究。比较3组对象超声心动图参数如左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、左室射血分数、主动脉窦内径等的变化，并分析甲状腺功能状态对3组研究对象心脏结构与功能的影响。结果 对照组、SCH组及甲减组患者的LVEDD分别为（47.69±4.13）、（45.33±4.45）和（42.81±4.26）mm，3组差异有统计学意义（P<0.05）。对照组、SCH组及甲减组患者的LVESD分别为（29.69±3.34）、（27.45±4.16）和（26.48±3.89）mm，3组差异有统计学意义（P<0.05）。结论 SCH患者与甲状腺功能减退患者的LVEDD和LVESD减小，左心室功能降低。
英文摘要:
      Objective To analyze thecardiac structure and function changesusing echocardiography in patients with subclinical hypothyroidism (SCH) and patients with hypothyroidism. Methods We retrospectively studied the clinical data of patients admitted to Beijing Chao-Yang Hospital, Capital Medical Universitybetween 2011 to 2017,of whom 58 patients were recruited as hypothyroidism group and 21 as SCH group. Another 65 subjects with euthyroidism were selected as control group. Echocardiographic parameters such as left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction, and aortic sinus diameter were compared between the three groups. The effects of thyroid function status on cardiac structure and function in three groupswere analyzed. Results LVEDD in control group, SCH group, and hypothyroidism group was(47.69±4.13) mm, (45.33±4.45) mm and (42.81±4.26) mm, respectively, and the difference was statistically significant (P<0.05). LVESD in control group, SCH group and hypothyroidism group was (29.69±3.34) mm, (27.45±4.16) mm and (26.48±3.89) mm, respectively, andthe difference was statistically significant (P<0.05). Conclusion Patients with SCH and hypothyroidism have reduced LVEDD and LVESD and decreased left ventricular function.
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