| Objective To analyze the clinicopathological features and their correlation with the prognosis of breast cancer patients treated with breast-conserving therapy. Methods A retrospective analysis was performed on 206 female breast cancer patients who underwent breast-conserving therapy from the Second Affiliated Hospital of Anhui Medical University from Jan 2010 to Dec 2012, and the clinicopathological features of the patients were summarized. Kaplan-Meier univariate analysis was used to analyze the influence of clinicopathological features (age, menstrual status, pathological type, tumor size, lymph node status, hormone receptor status, Ki-67 index, Her-2 expression status and neurovascular infiltration) on the prognosis of the patients. Cox regression multivariate survival analysis was employedto examine the factors with statistical significance in univariate analysis.Results Univariate analysis showed that there was no significant difference in the 5-year survival rate of patients of different age(P>0.05). There were significant differences in different menstrual status, lymph node status, Ki-67 index and neurovascular invasion(P<0.05).Multivariate analysis showed that menstrual status, lymph node status and Ki-67 index were correlated with the prognosis of breast-conserving therapy(P<0.05). Conclusion The age of breast cancer patients is not correlated to the prognosis of breast-conserving therapy. Menopause, lymph node metastasis and Ki-67 index are independent prognostic factors of breast cancer patients with breast-conserving therapy. |
