| Objective To investigate the influence of triple regimen, quadruple regimen and sequential regimen on clinical effects and safety of chronic gastritis with Hp infection for active stage. Methods A total of 180 patients with chronic gastritis with Hp infection for active stage were chosen in the period from June 2015 to June 2017 in our hospital and randomly divided into three groups, namely group A (60 patients) with triple regimen, group B (60 patients) with quadruple regimen and group C (60 patients) with sequential regimen, and the pain relief rate, symptom relief time, Hp eradication rate, adverse reaction incidence and recurrence rate after follow-up of three groups were compared. Results The pain relief rate of group C was significantly higher than that of group A and group B (P<0.05). The pain and digestive tract symptom relief time of group C was significantly shorter than that of group A and group B (P<0.05). The Hp eradication rate of group C was significantly higher than that of group A and group B (P<0.05). The adverse reaction incidence of group C was significantly lower than that of group A and group B (P<0.05). The recurrence rate of group C in 6 months and 12 months of follow-up was significantly higher than that of group A and group B (P<0.05). Conclusion Compared with triple regimen and quadruple regimen, sequential regimen in the treatment of chronic gastritis with Hp infection for active stage can efficiently reduce the pain relief degree, promote the symptom improvement, increase the Hp eradication rate, avoid the long-term recurrence and reduce the risk of adverse reactions. |
