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| 合肥市某单位体检人群25-羟维生素D水平与血脂的相关性 |
| Association between 25-hydroxy vitamin D and serum lipid in health check-up subjects of a unit in Hefei city |
| 投稿时间：2018-12-05 |
| DOI：10.3969/j.issn.1000-0399.2019.11.026 |
| 中文关键词: 25-羟维生素D 血脂 维生素D缺乏 体检 |
| 英文关键词: 25-hydroxyvitamin D serum lipid Vitamin D deficiency Health check-up |
| 基金项目:安徽省公益性技术应用研究（项目编号：1704f0804019） |
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| 中文摘要: |
| 目的 探讨合肥市某单位体检人群25-羟维生素D[25-（OH）D]水平与血脂的关系。方法 选取2016年5月在安徽医科大学第一附属医院健康体检的合肥市某单位人员共810例为研究对象，测量810例研究对象血清25-（OH）D以及总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）和低密度脂蛋白（LDL-C）等血脂指标。采用Pearson相关性分析和多元线性回归进行25-（OH）D与血脂各指标关系的多因素分析。结果 810例研究对象25-（OH）D平均浓度为（15.81±4.87）ng/mL，其中25-（OH）D缺乏者占67.7%，严重缺乏者占13.0%。Pearson相关分析显示25-（OH）D与TC、三酰甘油对数值（lgTG）和HDL-C均呈负相关（P<0.05），多因素分析显示血清25-（OH）D与TC （β值=-0.015，95% CI=-0.029～-0.002，P=0.021）和lgTG （β值=-0.008，95% CI=-0.011～-0.005，P<0.001）呈显著负相关。结论 合肥市某单位体检人群25-（OH）D缺乏率高，血清25-（OH）D水平与TC和TG存在负相关。 |
| 英文摘要: |
| Objective To explore the association between 25-hydroxy vitamin D [25-(OH)D] and serum lipid in health check-up subjects of a unit in Hefei city. Methods A total of 810 subjects were enrolled from a unit of Hefei city which underwent health examination in Health Management Center of the First Affiliated Hospital of Anhui Medical University. Serum 25-(OH)D, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were collected in May 2016. Pearson correlation and multiple linear regression were used to analyze the relationship between 25-(OH)D and serum lipid. Results The average level of 25-(OH)D was (15.81±4.87) ng/mL. 80.6% subjects had vitamin D deficiency, with 13.0% severely deficient. Pearson correlation analysis showed that 25-(OH)D had a significant negative correlation with TC, lgTG, HDL-C. Multivariate linear regression analysis showed that 25-(OH)D were significantly negatively associated with TC (β=-0.015, 95%CI=-0.029~-0.002, P=0.021) and lgTG (β=-0.008, 95%CI=-0.011~-0.005, P<0.001). Conclusions The rate of 25-(OH)D deficiency is high in health check-up subjects of a unit in Hefei city. 25-(OH)D has a significant negative relationship with TC and TG. |
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