Objective To explore the effect of multiple pregnancy reduction (MPR) on pregnancy outcomes,pregnancy complicationsand neonatal birth outcomes. Methods From January 2005 to January 2016, 479 pregnant women undergoing MPR were collected as pregnancy reduction group in the Reproductive Medicine Center,the First Affiliated Hospital of Anhui Medical University.At the same time,243 women who obtained clinical pregnancy were collected as control group. The pregnancy outcomes, pregnancy complicationsand neonatal birth outcomes were compared between the two groups. According to the number of embryos retained after MPR, the pregnancy reductiongroup was divided into two sub-groups:retained twin group (n=245) and retained single group (n=234). According to the number of pregnant embryos, the control group was divided into two sub-groups:regular twin group (n=133) and regular single group (n=110). The pregnancy outcomes,pregnancy complications and neonatal birth outcomes were compared.Results The incidence of spontaneous abortion in pregnancy reduction group (the retained twin group was 10.61% and the retained single group was 9.83%) was higher than that in regular twin group (0.75%), the incidence of spontaneous abortion in retained twin group was higher than that in regular single group(3.64%), andthe differenceswere all statistically significant(P < 0.05). The incidence of hypertensive disorder complication pregnancy, preterm premature rupture of the membrane, premature delivery and the low birth weight in retained twin group (8.98%,13.47%, 41.10% and 42.30%,respectively) and regular twin group(9.02%,11.28%,39.39% and 42.80%, respectively) were all higher than those in retained single group and regular single group, the average birth weight of the newborn waslower than that of retained single group and regular single group,andthe differences were all statistically significant(P < 0.05). Conclusions MPR may increase the risk of spontaneous abortion and spontaneous pregnancy loss. The number of retained embryos after MPR or the embryo number of normal pregnancy is an important factor affecting pregnancy complications and neonatal birth outcomes. |