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| 多沙唑嗪联合帕罗西汀治疗非细菌性慢性前列腺炎的疗效 |
| Therapeutic effect of doxazosin combined with paroxetine on non-bacterial chronic prostatitis |
| 投稿时间：2019-04-17 |
| DOI：10.3969/j.issn.1000-0399.2020.01.003 |
| 中文关键词: 多沙唑嗪 帕罗西汀 非细菌性慢性前列腺炎 |
| 英文关键词: Doxazosin Paroxetine Non-bacterial chronic prostatitis Treatment |
| 基金项目:深圳市龙华区科技创新资金项目（项目编号：2017138） |
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| 中文摘要: |
| 目的 观察多沙唑嗪联合帕罗西汀治疗非细菌性慢性前列腺炎的疗效。方法 选择2017年6月至2018年6月深圳市龙华区中心医院门诊治疗的非细菌性慢性前列腺炎患者120例为研究对象，采用随机数字表法分为对照组和观察组，每组60例。对照组给予单一多沙唑嗪治疗，观察组给予多沙唑嗪联合帕罗西汀治疗，连续治疗4个疗程（7 d为1个疗程）。比较两组的疗效和不良反应，观察两组治疗前后血清白细胞介素-2（IL-2）、C-反应蛋白（CRP）、肿瘤坏死因子γ（TNF-γ）水平的变化，评估两组治疗后机体炎症及焦虑、抑郁等负性情绪改善情况。结果 观察组治疗总有效率（96.67%）高于对照组（86.67%），差异有统计学意义（P<0.05）；观察组不良反应发生率（8.33%）高于对照组（6.67%），但差异无统计学意义（P>0.05）。与治疗前比较，治疗后两组患者慢性前列腺炎症状（NIH-CPSI）评分、焦虑自评量表（SAS）及抑郁自评量表（SDS）评分均降低，IL-2、CRP以及TNF-γ等细胞因子水平均降低，且观察组上述指标降幅均高于对照组，差异均有统计学意义（P<0.05）。结论 多沙唑嗪联合帕罗西汀治疗非细菌性慢性前列腺炎疗效确切，可缓解患者负性情绪和机体炎性症状，值得推广应用。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of doxazosin combined with paroxetine in the treatment of non-bacterial chronic prostatitis. Methods A total of 120 patients with non-bacterial chronic prostatitis who were treated in central hospital of Longhua district, Shenzhen from June 2017 to June 2018 were enrolled in the study. They were randomly divided into the control group and the observation group, 60 cases in each group.The control group was given a single doxazosin treatment, and the observation group was given doxazosin plus paroxetine for 4 courses of treatment (7 days for 1 course). The efficacy and adverse reactions of the two groups were compared. The changes of serum interleukin-2 (IL-2), C-reactive protein (CRP) and tumor necrosis factor γ (TNF-γ) levels were analyzed before and after treatment. To evaluate the improvement of negative emotions such as inflammation and anxiety and depression in the two groups after treatment.Results The total effective rate was 96.67% in the observation group and 86.67% in the control group. The difference between the two groups was statistically significant (P<0.05). The incidence of adverse reactions was 8.33% in the observation group and 6.67% in the control group. The difference was not statistical. Academic significance (P>0.05). Before treatment, there was no significant difference in serum inflammatory factor level, anxiety self-rating scale (SAS) and depression self-rating scale (SDS) between the two groups (P>0.05). The scores (NIH-CPSI), serum inflammatory factor levels, SAS and SDS scores were significantly lower, and the differences between the groups were statistically significant (P<0.05). Conclusion Doxazosin combined with paroxetine is effective in the treatment of non-bacterial chronic prostatitis, which can significantly alleviate the negative emotions and inflammatory symptoms of patients, which is worthy of promotion. |
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