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| 371例慢性心力衰竭患者随访一年死亡的相关危险因素分析 |
| Analysis of related risk factors of one-year prognosis of 371 patients with chronic heart failure |
| 投稿时间：2019-12-03 |
| DOI：10.3969/j.issn.1000-0399.2020.08.009 |
| 中文关键词: 慢性心力衰竭 近期预后 下肢水肿 N末端脑利钠肽前体 心肌肌钙蛋白I |
| 英文关键词: Chronic heart failure Recent prognosis N-terminal pro-brain nitric peptide cardiac troponin I |
| 基金项目:三亚市医疗卫生科技创新项目（项目编号：YW1220） |
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| 中文摘要: |
| 目的 探讨慢性心力衰竭（CHF）患者随访1年的预后情况及其危险因素。方法 对2015年7月至2018年6月371例在三亚中心医院（海南省第三人民医院）住院的CHF患者进行1年随访，依据患者是否死亡将其分为死亡组（74例）和存活组（297例）；分析患者的预后情况，采用logistic回归法筛选影响CHF患者近期预后的危险因素。结果 CHF患者1年病死率为19.95%（74/371）；多因素logistic回归分析结果显示，高龄（≥70岁）（OR=2.212）、心功能Ⅳ级（OR=3.618）、下肢水肿（OR=4.354）、低左心室射血分数（LVEF）（OR=4.773）、高N末端脑利钠肽前体（NT-proBNP）（OR=5.280）及心肌肌钙蛋白（cTnI）（OR=2.670）均为影响CHF患者1年死亡预后的危险因素。结论 CHF患者近期预后较差、病死率较高，应针对年龄≥70岁、心功能Ⅳ级、下肢水肿、LVEF<50%、NT-proBNP>3 600 pmol/L及cTnI>0.5 μg/L的患者早期采取预防和治疗措施，从而改善患者预后。 |
| 英文摘要: |
| Objective To explore the one-year prognosis and its correlated risk factors of patients with chronic heart failure (CHF). Methods A following-up study wascarried outin 371 cases of CHF patients admitted to Sanya Central Hospital from July2015 to June2018with one-year followup.These patients were divided into death group (74 cases) and survival group (297 cases) according to whether or not deathhappenedwithin one year. The recent prognosis was analyzed, and the correlated risk factors were screened by multiple factors logistic regression method. Results The case fatality rate of CHF patients within one year was 19.95% (74/371). Multiple factors logistic regression analysis result showed that the risk factors of one-year prognosis of CHF patients included high age (OR=2.212), Ⅳ level of heart function (OR=3.618), edema of lower extremity (OR=4.354), low level LVEF (OR=4.773), high levels of NT-proBNP (OR=5.280) and cTnI (OR=2.670). Conclusion Age ≥ 70 years old, cardiac function grade IV, extremity edema, LVEF<50%, NT proBNP>3 600pmol/L and cTnI>0.5μg/Lare the risk factors of death in CHF patients one year after discharge. Early prevention and treatment measures should be taken to improve the prognosis of CHF patients. |
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