|
| 血清超敏C反应蛋白白介素6与冠状动脉病变程度的相关性 |
| Correlation between serum high sensitive C-reactive protein and interleukin-6 and severity of coronary artery disease |
| 投稿时间：2020-04-19 |
| DOI：10.3969/j.issn.1000-0399.2020.09.007 |
| 中文关键词: 冠心病 超敏C反应蛋白 白介素-6 |
| 英文关键词: Coronary heart disease High sensitive C-reactive protein Interleukin-6 |
| 基金项目:四川省医学科研课题（项目编号：S18073） |
|
| 摘要点击次数: 917 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的 探讨血清超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）与冠状动脉病变严重程度的相关性。方法 选择2017年2月至2019年12月在昆明理工大学附属攀钢集团总医院住院并接受冠状动脉造影（CAG）检查的患者317例，根据CAG检查结果，将其分为正常组（n=81）与冠心病（CHD）组（n=236）。依据冠状动脉Gensini积分，将CHD组患者分为低危组132例（<20分）、中危组78例（20～40分）和高危组26例（>40分）。比较各组患者临床资料、血清hs-CRP和IL-6水平的差异。结果 CHD组患者年龄为（57.82±9.54）岁、高血压109例（46.19%）、糖尿病75例（31.78%）、低密度脂蛋白水平为（3.69±1.34）mmol/L、hs-CRP水平为（18.21±9.79）mg/L、IL-6水平为（25.70±12.62）pg/L，均高于正常组，差异有统计学意义（P<0.05）。低、中及高危组患者血清hs-CRP、IL-6水平进行比较，差异均有统计学意义（P<0.05）。高危组患者hs-CRP水平为（29.47±17.91）mg/L、IL-6水平为（35.31±8.69）pg/L，均高于低、中危组，差异有统计学意义（P<0.05）。血清hs-CRP、IL-6水平与冠状动脉Gensini积分呈正相关（P<0.05）。结论 血清hs-CRP和IL-6与冠状动脉病变程度具有一定的相关性。 |
| 英文摘要: |
| Objective To investigate the correlation between serum high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and severity of coronary artery disease in patients with coronary heart disease (CHD). Methods February 2017 to December 2019, 317 patients with coronary angiography were selected from Department of Cardiology, Pangang Group General Hospital Affiliated to Kunming University of Technology. The patients were divided in to normal group 81 cases and CHD group 236 cases. According to the Gensini score, CHD patients were divided into low-risk group 132 cases (<20), medium risk group 78 cases(20~40) and high-risk group 26 cases (>40). We analyzed the clinical data, serum hs-CRP and IL-6. Results The age of the patients was 57.82 ±9.54 years old, there were 109 cases of hypertension(46.19%) and 75 cases of diabetes(31.78%),LDL was (3.69±1.34)mmol/L,hs-CRP was(18.21±9.79)mg/L,IL-6 was (25.70±12.62)pg/L in the coronary heart disease group. They were all higher than those of the control group.They were all higher in the coronary heart disease group than those of the control group. The difference between the two groups was statistically significant (P <0.05). There were significant differences in the level of hs-CRP or IL-6 between low-risk group, medium risk group and high-risk group (P<0.05).The levels of hs-CRP was(29.47±17.91)mg/L and IL-6 was(35.31±8.69)pg/L in the high-risk group, which were higher than those in low and medium risk groups (P<0.05). There was a positive correlation between the levels of serum hs-CRP and IL-6 and coronary Gensini score (P<0.05).Conclusion The levels of serum hs-CRP and IL-6 are correlated with the degree of coronary artery disease. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
